3 Result(s)
within
Teresa Poggio
Hematology
-
Article
Open AccessGab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo
Internal tandem duplications (ITD) of the FMS-like tyrosine kinase 3 (FLT3) predict poor prognosis in acute myeloid leukemia (AML) and often co-exist with inactivating DNMT3A mutations. In vitro studies implicate...
-
Article
Open AccessThe IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML
FLT3-ITD is the most predominant mutation in AML being expressed in about one-third of AML patients and is associated with a poor prognosis. Efforts to better understand FLT3-ITD downstream signaling to possib...
-
Article
Open AccessExistence of reprogrammed lymphoma stem cells in a murine ALCL-like model
While cancer stem cells are well established in certain hematologic and solid malignancies, their existence in T cell lymphoma is unclear and the origin of disease is not fully understood. To examine the exist...
