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Open AccessResearch on safety condition assessment methodology for single tower steel box girder suspension bridges over the sea based on improved AHP-fuzzy comprehensive evaluation
In order to propose a reliable method for assessing the safety condition for single-tower steel box girder Suspension bridges over the sea, a condition monitoring system is established by installing sensors on...
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Article
Open AccessEnhanced YOLO v3 for precise detection of apparent damage on bridges amidst complex backgrounds
A bridge disease identification approach based on an enhanced YOLO v3 algorithm is suggested to increase the accuracy of apparent disease detection of concrete bridges under complex backgrounds. First, the YOL...
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Article
Open AccessDevelopment of an invasion score based on metastasis-related pathway activity profiles for identifying invasive molecular subtypes of lung adenocarcinoma
The invasive capacity of lung adenocarcinoma (LUAD) is an important factor influencing patients’ metastatic status and survival outcomes. However, there is still a lack of suitable biomarkers to evaluate tumor...
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Article
Open AccessIdentification of a bile acid and bile salt metabolism-related lncRNA signature for predicting prognosis and treatment response in hepatocellular carcinoma
Bile acids and salts have been shown to play a role in liver carcinogenesis through DNA damage, inflammation, and tumor proliferation. However, the correlation between bile acid metabolism and hepatocellular c...
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Article
Open AccessAn immune indicator based on BTK and DPEP2 identifies hot and cold tumors and clinical treatment outcomes in lung adenocarcinoma
In lung adenocarcinoma (LUAD), immune heterogeneity of hot and cold tumors has been recognized as one of the major factors affecting immunotherapy and other common treatments. However, there is still a lack of...
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Article
Open AccessClinical features and shared mechanisms of chronic gastritis and osteoporosis
Chronic gastritis (CG) and osteoporosis (OP) are common and occult diseases in the elderly and the relationship of these two diseases have been increasingly exposed. We aimed to explore the clinical characteri...
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Article
Open AccessDiffusion interface layer controlling the acceptor phase of bilayer near-infrared polymer phototransistors with ultrahigh photosensitivity
The narrow bandgap of near-infrared (NIR) polymers is a major barrier to improving the performance of NIR phototransistors. The existing technique for overcoming this barrier is to construct a bilayer device (...
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Article
Open AccessMechanism of quercetin therapeutic targets for Alzheimer disease and type 2 diabetes mellitus
Quercetin has demonstrated antioxidant, anti-inflammatory, hypoglycemic, and hypolipidemic activities, suggesting therapeutic potential against type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD). In ...
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Article
Open AccessA dynamic prediction model for prognosis of acute-on-chronic liver failure based on the trend of clinical indicators
Acute-on-chronic liver failure (ACLF) is a dynamic syndrome, and sequential assessments can reflect its prognosis more accurately. Our aim was to build and validate a new scoring system to predict short-term p...
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Article
Open AccessAncient genomes from northern China suggest links between subsistence changes and human migration
Northern China harbored the world’s earliest complex societies based on millet farming, in two major centers in the Yellow (YR) and West Liao (WLR) River basins. Until now, their genetic histories have remaine...
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Open AccessQuantitative analysis of breast tumours aided by three-dimensional photoacoustic/ultrasound functional imaging
In this pilot study, we explored a quantitative method to analyse characteristics of breast tumours using 3D volumetric data obtained from a three-dimensional (3D) photoacoustic/ultrasound (PA/US) functional i...
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Open AccessInterplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis
The Anaphase Promoting Complex (APC) coactivator Cdh1 drives proper cell cycle progression and is implicated in the suppression of tumorigenesis. However, it remains elusive how Cdh1 restrains cancer progressi...
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Article
Open AccessK27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling
BRAF plays an indispensable role in activating the MEK/ERK pathway to drive tumorigenesis. Receptor tyrosine kinase and RAS-mediated BRAF activation have been extensively characterized, however, it remains und...
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Article
Open AccessUnderstanding Trap Effects on Electrical Treeing Phenomena in EPDM/POSS Composites
POSS (polyhedral oligomeric silsesquioxane) provides an interesting alternative nano-silica and has the potential of superior dielectric properties to restrain electrical degradation. By incorporating POSS int...
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Open AccessTranscriptome analysis reveals carbohydrate-mediated liver immune responses in Epinephelus akaara
As the cheapest energy source, carbohydrates are used in fish feeds to improve physical quality and reduce catabolism of proteins and lipids. The liver is the primary organ for metabolism and is also an import...
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Article
Open AccessThe liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways
Long noncoding RNAs (lncRNAs) play important roles in various biological processes such as proliferation, cell death and differentiation. Here, we show that a liver-enriched lncRNA, named liver fibrosis-associ...
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Article
Open AccessImproving “color rendering” of LED lighting for the growth of lettuce
Light plays a vital role on the growth and development of plant. On the base of white light with high color rendering to the benefit of human survival and life, we proposed to improve “color rendering” of LED ...
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Article
Open AccessFemale gender lost protective effect against disease progression in elderly patients with chronic hepatitis B
Female gender and younger age are protective factors against disease progression in chronic hepatitis B (CHB). However, it is not clear whether the disease progression still remains slow in elderly females. Th...
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Article
Open AccessShort-term intratracheal use of PEG-modified IL-2 and glucocorticoid persistently alleviates asthma in a mouse model
Regulatory T (Treg) cells play an important role in allergic airway diseases and upregulation of Treg cells is a potential therapeutic strategy for asthma. In this study, we show that short-term intratracheal ...
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Open AccessDe Hass-van Alphen and magnetoresistance reveal predominantly single-band transport behavior in PdTe2
Research on two-dimensional transition metal dichalcogenides (TMDs) has grown rapidly over the past several years, from fundamental studies to the development of next generation technologies. Recently, it has ...