30 Result(s)
within
Tao han
Life Sciences
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Article
Integrated multi-omics analysis and machine learning to refine molecular subtypes, prognosis, and immunotherapy in lung adenocarcinoma
Lung adenocarcinoma (LUAD) has a malignant characteristic that is highly aggressive and prone to metastasis. There is still a lack of suitable biomarkers to facilitate the refinement of precision-based therape...
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Integrating bulk-RNA sequencing and single-cell sequencing analyses to characterize adenosine-enriched tumor microenvironment landscape and develop an adenosine-related prognostic signature predicting immunotherapy in lung adenocarcinoma
The adenosine-signaling axis has been recognized as an important immunomodulatory pathway in tumor immunity. However, the biological role of the adenosine-signaling axis in the remodeling of the tumor microenv...
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Open AccesslncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization
Hepatic fibrosis is a common consequence of chronic liver diseases without approved antifibrotic therapies. Long noncoding RNAs (lncRNAs) play an important role in various pathophysiological processes. However...
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Open AccessHLF promotes ovarian cancer progression and chemoresistance via regulating Hippo signaling pathway
Hepatic leukemia factor (HLF) is aberrantly expressed in human malignancies. However, the role of HLF in the regulation of ovarian cancer (OC) remains unknown. Herein, we reported that HLF expression was upreg...
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Open AccessFerroptosis as a potential target for cancer therapy
Ferroptosis is a recently discovered essential type of cell death that is mainly characterized by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a double-edged sword in hu...
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Molecular cloning, characterization, and expression patterns of the hatching enzyme genes during embryonic development of pikeperch (Sander lucioperca)
Hatching enzyme (HE) is the most critical enzyme in the process of fish hatching. Pikeperch, Sander lucioperca, is one of economical and ferocious fish with long embryonic incubation and its long and irregular ha...
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Open AccessRegulation of the tumor immune microenvironment by cancer-derived circular RNAs
Circular RNA (circRNAs) is a covalently closed circular non-coding RNA formed by reverse back-splicing from precursor messenger RNA. It is found widely in eukaryotic cells and can be released to the surroundin...
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Open AccessDownregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis
Mucin 15 (MUC15) is reportedly aberrant in human malignancies, including hepatocellular carcinoma (HCC). However, the role of MUC15 in the regulation of liver tumor-initiating cells (T-ICs) remains unknown. He...
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Oxygen isotope temperature calibrations for modern Tridacna shells in western Pacific
The oxygen isotope ratio of carbonate in Tridacna shell (δ18Oshell) is assumed to be precipitated in isotopic equilibrium with surrounding seawater and thus reflects a combination of the Sea surface temperature (...
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Open AccessAssessing reproducibility of inherited variants detected with short-read whole genome sequencing
Reproducible detection of inherited variants with whole genome sequencing (WGS) is vital for the implementation of precision medicine and is a complicated process in which each step affects variant call qualit...
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Open AccessXDeathDB: a visualization platform for cell death molecular interactions
Lots of cell death initiator and effector molecules, signalling pathways and subcellular sites have been identified as key mediators in both cell death processes in cancer. The XDeathDB visualization platform ...
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Open AccessTranscriptional factor ATF3 promotes liver fibrosis via activating hepatic stellate cells
The excessive accumulation of extracellular matrix (ECM) is a key feature of liver fibrosis and the activated hepatic stellate cells (HSCs) are the major producer of ECM proteins. However, the precise mechanis...
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Effects of dietary protein intake on the oxidation of glutamate, glutamine, glucose and palmitate in tissues of largemouth bass (Micropterus salmoides)
Largemouth bass (Micropterus salmoides, a carnivorous fish native to North America) prefers to utilize amino acids as energy sources rather than glucose and fatty acids. However, little is known about the nutriti...
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Open AccessSilencing lncRNA Lfar1 alleviates the classical activation and pyoptosis of macrophage in hepatic fibrosis
Hepatic fibrosis is a common pathological consequence of a sustained wound healing response to continuous liver injury, characterized by increased production and accumulation of extracellular matrix. If unreso...
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Open AccessPioglitazone prevents cholesterol gallstone formation through the regulation of cholesterol homeostasis in guinea pigs with a lithogenic diet
The cholesterol gallstones diseases (CGD) is highly correlated with metabolic syndrome and type 2 diabetes. The present study aimed to investigate preventive effects of pioglitazone (PIO), an antidiabetic drug...
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Open AccessStatus of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice
Nonalcoholic fatty liver disease (NAFLD) is a major health problem and a leading cause of chronic liver disease in the United States and Western countries. In humans, genetic factors greatly influence individu...
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Salidroside Ameliorates Cd-Induced Calcium Overload and Gap Junction Dysfunction in BRL 3A Rat Liver Cells
It is known that cadmium (Cd) induces cytotoxicity via Ca2+ signaling, although the underlying mechanism is unclear. Here, we studied the molecular mechanisms of Cd-induced cytotoxicity in BRL 3A cells, a rat liv...
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Effect of dietary lipid level on growth performance, feed utilization and body composition by juvenile red spotted grouper (Epinephelus akaara)
This study was designed to determine the effect of dietary lipid level on growth performance, feed utilization and body composition of juvenile red spotted grouper, Epinephelus akaara. Triplicate groups of 12 fis...
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A novel silent deletion, an insertion mutation and a nonsense mutation in the TCOF1 gene found in two Chinese cases of Treacher Collins syndrome
Treacher Collins syndrome (TCS) is the most common and well-known craniofacial disorder caused by mutations in the genes involved in pre-rRNA transcription, which include the TCOF1 gene. This study explored the r...
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Retinol-binding protein 4 as a risk factor for cholesterol gallstone formation
Retinol-binding protein 4 (RBP4) is closely associated with a variety of abnormal glycolipid metabolism diseases such as insulin resistance, obesity, diabetes mellitus, and metabolic syndrome. Part 1 Twenty-four ...
