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Article
Evaluation of mutagenic susceptibility of different stages in germ cell development of Caenorhabditis elegans using whole genome sequencing
In contrast to somatic mutations, mutations in germ cells affect every cell of any organism derived from the germ cell and therefore are related to numerous genetic diseases. However, there is no suitable assa...
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Article
Open AccessAssessing reproducibility of inherited variants detected with short-read whole genome sequencing
Reproducible detection of inherited variants with whole genome sequencing (WGS) is vital for the implementation of precision medicine and is a complicated process in which each step affects variant call qualit...
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Article
Open AccessHidden biases in germline structural variant detection
Genomic structural variations (SV) are important determinants of genotypic and phenotypic changes in many organisms. However, the detection of SV from next-generation sequencing data remains challenging.
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Article
Open AccessInforming selection of drugs for COVID-19 treatment through adverse events analysis
Coronavirus disease 2019 (COVID-19) is an ongoing pandemic and there is an urgent need for safe and effective drugs for COVID-19 treatment. Since develo** a new drug is time consuming, many approved or inves...
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Article
Open AccessCorrection to: Similarities and differences between variants called with human reference genome HG19 or HG38
After publication of this supplement article
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Article
Open AccessSimilarities and differences between variants called with human reference genome HG19 or HG38
Reference genome selection is a prerequisite for successful analysis of next generation sequencing (NGS) data. Current practice employs one of the two most recent human reference genome versions: HG19 or HG38....
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Article
Whole genome sequencing analysis of small and large colony mutants from the mouse lymphoma assay
The Thymidine kinase (Tk) gene forward mutation assay, known as the mouse lymphoma assay (MLA), has been widely used for evaluating the genotoxicity of chemical agents. A striking morphological feature of Tk muta...
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Article
Open AccessThe genome of Mesobuthus martensii reveals a unique adaptation model of arthropods
Representing a basal branch of arachnids, scorpions are known as ‘living fossils’ that maintain an ancient anatomy and are adapted to have survived extreme climate changes. Here we report the genome sequence of M...
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Article
Open AccessOptimizing hybrid assembly of next-generation sequence data from Enterococcus faecium: a microbe with highly divergent genome
Sequencing of bacterial genomes became an essential approach to study pathogen virulence and the phylogenetic relationship among close related strains. Bacterium Enterococcus faecium emerged as an important nosoc...
