-
Article
C-Reactive Protein-Albumin Ratio Predicts Objective Response to Enfortumab Vedotin in Metastatic Urothelial Carcinoma
Enfortumab vedotin (EV), an antibody-drug conjugate that targets Nectin-4, is used for patients with metastatic urothelial carcinoma who have experienced progression on platinum-based chemotherapy and checkpoi...
-
Article
Open AccessTime-course transcriptome data of silk glands in day 0–7 last-instar larvae of Bombyx mori (w1 pnd strain)
Time-course transcriptome expression data were constructed for four parts of the silk gland (anterior, middle, and posterior parts of the middle silk gland, along with the posterior silk gland) in the domestic...
-
Article
Prologue: Special Spotlight Issue on Japan
-
Article
Open AccessIsobutyric acid enhances the anti-tumour effect of anti-PD-1 antibody
The low response rate of immune checkpoint inhibitors (ICIs) is a challenge. The efficacy of ICIs is influenced by the tumour microenvironment, which is controlled by the gut microbiota. In particular, intesti...
-
Article
Durable Response to Enfortumab Vedotin Compared to Re-challenging Chemotherapy in Metastatic Urothelial Carcinoma After Checkpoint Inhibitors
Enfortumab vedotin (EV), an antibody–drug conjugate targeting Nectin-4, has been used for patients with metastatic urothelial carcinoma (mUC) after progressing on checkpoint inhibitors (CPIs). Re-challenging c...
-
Article
Open AccessComparison of the efficacy of enfortumab vedotin between patients with metastatic urothelial carcinoma who were treated with avelumab or pembrolizumab: real-world data from a multi-institutional study in Japan
Enfortumab vedotin (EV) is a novel antibody–drug conjugate approved for metastatic urothelial carcinoma (UC) refractory to prior treatment with immune checkpoint inhibitors (ICIs). However, the difference in e...
-
Article
Open AccessButyricimonas is a key gut microbiome component for predicting postoperative recurrence of esophageal cancer
Recently, intestinal bacteria have attracted attention as factors affecting the prognosis of patients with cancer. However, the intestinal microbiome is composed of several hundred types of bacteria, necessita...
-
Article
Nephron-sparing ureteroscopic surgery vs. radical nephroureterectomy: comparable survival-outcomes in upper tract urothelial carcinoma
This study investigates the utility of ureteroscopic surgery (URS) as an alternative to radical nephroureterectomy (RNU) in managing upper tract urothelial carcinoma (UTUC), with a focus on survival outcomes a...
-
Article
Open AccessThe Impact of FGFR3 Alterations on the Tumor Microenvironment and the Efficacy of Immune Checkpoint Inhibitors in Bladder Cancer
Currently, only limited knowledge is available regarding the phenotypic association between fibroblast growth factor receptor 3 (FGFR3) alterations and the tumor microenvironment (TME) in bladder cancer (BLCA).
-
Article
Open AccessMonitoring of equatorial plasma bubbles using aeronautical navigation system: a feasibility study
It has long been known that field-aligned irregularities within equatorial plasma bubbles (EPBs) can cause long-range propagation of radio waves in the VHF frequencies such as those used for TV broadcasting th...
-
Article
Characteristics of the takeout protein ce-0330 in the silkworm, Bombyx mori (Lepidoptera: Bombycidae)
Insect juvenile hormone (JH)-binding protein (JHBP) transports JH in the hemolymph. The JHBP gene is a member of the takeout gene superfamily, which has more than 10 genes belonging to each species and that play ...
-
Article
Correction to: General theory of interpolation error estimates on anisotropic meshes
-
Article
Impact of intravascular ultrasound parameters and platelet reactivity on primary patency after drug-coated balloon angioplasty for femoropopliteal artery disease
Although the superiority of DCBs to uncoated balloon angioplasty for the treatment of femoropopliteal (FP) lesions has been demonstrated, the association of clinical factors, including anatomical features eval...
-
Article
Open AccessStatistical analysis for EUV dynamic spectra and their impact on the ionosphere during solar flares
The X-rays and extreme ultraviolet (EUV) emitted during solar flares can rapidly change the physical composition of Earth’s ionosphere, causing space weather phenomena. It is important to develop an accurate u...
-
Article
Open AccessCRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer
Prostate cancer harboring BRCA1/2 mutations are often exceptionally sensitive to PARP inhibitors. However, genomic alterations in other DNA damage response genes have not been consistently predictive of clinical ...
-
Chapter and Conference Paper
Numerical Simulations of Semilinear Klein–Gordon Equation in the de Sitter Spacetime with Structure-Preserving Scheme
We perform some simulations of the semilinear Klein–Gordon equation in the de Sitter spacetime. We reported the accurate numerical results of the equation with the structure-preserving scheme (SPS) in an earli...
-
Protocol
Genome Editing of Silkworms
Silkworm is a lepidopteran insect that has been used as a model for a wide variety of biological studies. The microinjection technique is available, and it is possible to cause transgenesis as well as target g...
-
Chapter
Impact of Space Weather on Various Fields
The social impacts of space weather occur at different times in various fields. In this chapter, telecommunication, satellite navigation, electric power, satellite operation, radiation exposure onboard aircraf...
-
Article
Open AccessAnisotropic interpolation error estimates using a new geometric parameter
We present precise anisotropic interpolation error estimates for smooth functions using a new geometric parameter and derive inverse inequalities on anisotropic meshes. In our theory, the interpolation error i...
-
Article
Identification of post-procedural optical coherence tomography findings associated with the 1-year vascular response evaluated by coronary angioscopy
Optical coherence tomography (OCT) provides higher resolution intravascular imaging and allows detailed evaluations of stent implantation sites post-percutaneous coronary intervention (PCI). Coronary angioscop...
