12 Result(s)
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Article
Open AccessGeneration of a recombinant temperature-sensitive influenza D virus
Influenza D virus (IDV) is a causative agent of the bovine respiratory disease complex (BRDC), which is the most common and costly disease affecting the cattle industry. For develo** a candidate vaccine viru...
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Open AccessA potential bat adenovirus-based oncolytic virus targeting canine cancers
Although a canine adenovirus (CAdV)-based oncolytic virus (OV) candidate targeting canine tumors has been reported, its oncolytic effect could be attenuated by CAdV vaccine-induced neutralizing antibodies in d...
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Article
Open AccessCharacterization of a novel species of adenovirus from Japanese microbat and role of CXADR as its entry factor
Recently, bat adenoviruses (BtAdVs) of genus Mastadenovirus have been isolated from various bat species, some of them displaying a wide host range in cell culture. In this study, we isolated two BtAdVs from Japan...
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Open AccessHeparin interacts with elongation factor 1α of Cryptosporidium parvum and inhibits invasion
Cryptosporidium parvum is an apicomplexan parasite that can cause serious watery diarrhea, cryptosporidiosis, in human and other mammals. C. parvum invades gastrointestinal epithelial cells, which have abundant g...
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Open AccessGellan sulfate inhibits Plasmodium falciparum growth and invasion of red blood cells in vitro
Here, we assessed the sulfated derivative of the microbial polysaccharide gellan gum and derivatives of λ and κ-carrageenans for their ability to inhibit Plasmodium falciparum 3D7 and Dd2 growth and invasion of r...
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Correction: Corrigendum: Analyses of Interactions Between Heparin and the Apical Surface Proteins of Plasmodium falciparum
Heparin, a sulfated glycoconjugate, reportedly inhibits the blood-stage growth of the malaria parasite Plasmodium falciparum. Elucidation of the inhibitory mechanism is valuable for develo** novel invasion-bloc...
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Open AccessCharacterization of the interaction between Toxoplasma gondii rhoptry neck protein 4 and host cellular β-tubulin
Toxoplasma rhoptry neck protein 4 (TgRON4) is a component of the moving junction macromolecular complex that plays a central role during invasion. TgRON4 is exposed on the cytosolic side of the host cell during i...
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Open AccessAnalyses of Interactions Between Heparin and the Apical Surface Proteins of Plasmodium falciparum
Heparin, a sulfated glycoconjugate, reportedly inhibits the blood-stage growth of the malaria parasite Plasmodium falciparum. Elucidation of the inhibitory mechanism is valuable for develo** novel invasion-bloc...
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Article
Open AccessA cell-based screening system for influenza A viral RNA transcription/replication inhibitors
Although two classes of antivirals, NA inhibitors and M2 ion channel blockers, are licensed for influenza treatment, dual resistant mutants, including highly pathogenic H5N1 viruses, have appeared. Alternative...
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In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
Analysis of a series of clinical isolates of the swine-origin H1N1 influenza virus reveals that in mammalian models (mice, ferrets and macaques) the current pandemic virus is associated with more severe diseas...
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Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors
The fact that the H5N1 bird flu virus circulating in Asia, Europe and Africa is unable to attach to human-type cell receptors has helped to prevent it from causing a worldwide epidemic of a human variant of th...
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Isolation of drug-resistant H5N1 virus
The full report on an H5N1 avian flu virus isolate resistant to Tamiflu (oseltamivir) has added to concerns about preparations for a flu pandemic. The virus was from a Vietnamese girl given the drug as both pr...
