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Article
Differential role of NSs genes in the neurovirulence of two genogroups of Akabane virus causing postnatal encephalomyelitis
Akabane virus (AKAV) is a member of the genus Orthobunyavirus, family Peribunyaviridae. In addition to AKAV strains that cause fetal Akabane disease, which is characterized by abortion in ruminants, some AKAV str...
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Article
Open AccessIsolation and genetic characterization of a mammalian orthoreovirus from Vespertilio sinensis in Japan
Throughout East Asia, Europe, and North America, mammalian orthoreovirus (MRV), for which bats have been proposed to be natural reservoirs, has been detected in a variety of domestic and wild mammals, as well ...
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Article
Open AccessGeneration of a recombinant temperature-sensitive influenza D virus
Influenza D virus (IDV) is a causative agent of the bovine respiratory disease complex (BRDC), which is the most common and costly disease affecting the cattle industry. For develo** a candidate vaccine viru...
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Article
Open AccessDirect evidence of fiber-protein-directed hemagglutination by canine adenoviruses
Canine adenoviruses (CAdVs) are divided into two serotypes, CAdV1 and CAdV2, whose members mainly cause infectious hepatitis and laryngotracheitis, respectively, in canids. To gain insight into the molecular b...
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Article
Complete genome sequence of a novel bat mastadenovirus C strain isolated from Rhinolophus cornutus in Japan
Here, we report a novel bat adenovirus strain isolated from apparently healthy bats of the species Rhinolophus cornutus in Japan. The genome of the isolate was 36,506 bp in length and encoded at least 33 proteins...
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Article
Open AccessA potential bat adenovirus-based oncolytic virus targeting canine cancers
Although a canine adenovirus (CAdV)-based oncolytic virus (OV) candidate targeting canine tumors has been reported, its oncolytic effect could be attenuated by CAdV vaccine-induced neutralizing antibodies in d...
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Article
Open AccessCharacterization of a novel species of adenovirus from Japanese microbat and role of CXADR as its entry factor
Recently, bat adenoviruses (BtAdVs) of genus Mastadenovirus have been isolated from various bat species, some of them displaying a wide host range in cell culture. In this study, we isolated two BtAdVs from Japan...
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Article
Bovine viral diarrhea virus non-structural protein NS4B induces autophagosomes in bovine kidney cells
Bovine viral diarrhea virus (BVDV) is an important pathogen in cattle that causes economic losses in livestock industries. Autophagy is an essential cell system for the maintenance of homeostasis and is induce...
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Article
Detection of bat hepatitis E virus RNA in microbats in Japan
Several recent studies have reported that various bat species harbor bat hepatitis E viruses (BatHEV) belonging to the family Hepeviridae, which also contains human hepatitis E virus (HEV). The distribution and e...
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Article
First isolation and characterization of pteropine orthoreoviruses in fruit bats in the Philippines
Pteropine orthoreovirus (PRV) causes respiratory tract illness (RTI) in humans. PRVs were isolated from throat swabs collected from 9 of 91 wild bats captured on the Mindanao Islands, The Philippines, in 2013....
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Article
Open AccessCharacterization of a Toxoplasma gondii calcium calmodulin-dependent protein kinase homolog
Toxoplasma gondii is an obligate intracellular parasite of the phylum Apicomplexa and a major pathogen of animals and immunocompromised humans, in whom it causes encephalitis. Understa...
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Article
Analysis of the entry mechanism of Crimean-Congo hemorrhagic fever virus, using a vesicular stomatitis virus pseudoty** system
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease causing severe hemorrhagic symptoms with a nearly 30 % case-fatality rate in humans. The experimental use of CCHF virus (CCHFV), which causes CCHF...
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Article
Open AccessHeparin interacts with elongation factor 1α of Cryptosporidium parvum and inhibits invasion
Cryptosporidium parvum is an apicomplexan parasite that can cause serious watery diarrhea, cryptosporidiosis, in human and other mammals. C. parvum invades gastrointestinal epithelial cells, which have abundant g...
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Article
Cats as a potential source of emerging influenza virus infections
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Article
Open AccessLambda-carrageenan treatment exacerbates the severity of cerebral malaria caused by Plasmodium berghei ANKA in BALB/c mice
There is an urgent need to develop and test novel compounds against malaria infection. Carrageenans, sulphated polysaccharides derived from seaweeds, have been previously shown to inhibit Plasmodium falciparum in...
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Article
Physical interaction between bovine viral diarrhea virus nonstructural protein 4A and adenosine deaminase acting on RNA (ADAR)
Bovine viral diarrhea virus (BVDV) is a positive-sense RNA virus known to produce double-stranded RNA (dsRNA) during its replication in the cytoplasm. Extended dsRNA duplexes can be hyperedited by adenosine de...
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Article
Open AccessGellan sulfate inhibits Plasmodium falciparum growth and invasion of red blood cells in vitro
Here, we assessed the sulfated derivative of the microbial polysaccharide gellan gum and derivatives of λ and κ-carrageenans for their ability to inhibit Plasmodium falciparum 3D7 and Dd2 growth and invasion of r...
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Article
Correction: Corrigendum: Analyses of Interactions Between Heparin and the Apical Surface Proteins of Plasmodium falciparum
Heparin, a sulfated glycoconjugate, reportedly inhibits the blood-stage growth of the malaria parasite Plasmodium falciparum. Elucidation of the inhibitory mechanism is valuable for develo** novel invasion-bloc...
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Article
Effects of dextran sulfates on the acute infection and growth stages of Toxoplasma gondii
Toxoplasma gondii is one of the most prevalent parasites, causing toxoplasmosis in various warm-blooded animals, including humans. Because of the broad range of hosts susceptible to T. gondii, it...
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Article
Open AccessCharacterization of the interaction between Toxoplasma gondii rhoptry neck protein 4 and host cellular β-tubulin
Toxoplasma rhoptry neck protein 4 (TgRON4) is a component of the moving junction macromolecular complex that plays a central role during invasion. TgRON4 is exposed on the cytosolic side of the host cell during i...
