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Open AccessCytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection
We report the systemic cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection. In patients with pneumonia, the serum levels of IFN-γ and IL-5 were significantly h...
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Article
Open AccessBRAFV600E mutation in anaplastic thyroid carcinomas and their accompanying differentiated carcinomas
Frequency of a BRAFV600E mutation in anaplastic thyroid carcinoma, which is thought to be derived mainly from papillary carcinoma by multi-step carcinogenesis, is much lower than that in papillary carcinomas. To ...
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Article
Open AccessClinical outcome and risk factors for recurrence in borderline ovarian tumours
We investigated the long-term prognosis of borderline ovarian tumours and determined risk factors for recurrence. One hundred and twenty-one borderline ovarian tumours treated between 1994 and 2003 at the part...
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Article
Open AccessHigh-throughput differential screening of mRNAs by serial analysis of gene expression: decreased expression of trefoil factor 3 mRNA in thyroid follicular carcinomas
To find mRNAs whose expression differs between thyroid follicular adenomas and carcinomas, a high-throughput analysis of mRNAs in these two tumours was performed. This method, named high-throughput differentia...
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Article
A novel apolipoprotein E5 variant with a 24-bp insertion causing hyperlipidemia
A tandem 24-bp insertion in the apolipoprotein E (apo E) gene was detected in a patient with elevated triglyceride, apolipoprotein (apo) CII, and apo CIII levels. This novel variant, apo E5ss, showed in position...
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Article
Open AccessQuantitative measurement of thyroglobulin mRNA in peripheral blood of patients after total thyroidectomy
Previous studies have reported the clinical usefulness of reverse transcription-polymerase chain reaction (RT-PCR) detection of thyroglobulin (TG) mRNA in the peripheral blood of patients with differentiated t...
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Article
Open AccessGene expression profiles in thyroid carcinomas
The gene expression profiles of human thyroid carcinomas were analysed by serial analysis of gene expression (SAGE) which allows quantitative and simultaneous analysis of a large number of transcripts. More th...
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Article
Restricted expression of oncofetal fibronectin mRNA in thyroid papillary and anaplastic carcinoma: an in situ hybridization study
Restricted expression of oncofetal fibronectin mRNA in the tissues of thyroid papillary and anaplastic carcinoma has recently been shown by both Northern blot analysis and reverse transcriptase polymerase chai...
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Article
High-resolution studies in patients with aniridia-Wilms tumor association, Wilms tumor or related congenital abnormalities
We attempted to determine wheter all cases of AWTA (anirida-Wilms tumor association) or any of the following groups of patients show 11p deletion: cases of Wilms tumor with congenital abnormalities other than ...