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Article
Trace Elements in Tissues of Whale Sharks (Rhincodon typus) Stranded in the Gulf of California, Mexico
Concentration of essential (Se, Zn and Cu) and non-essential (As, Cd, Hg and Pb) trace elements were measured in selected tissues of two dead whale sharks (Rhincodon typus) stranded in the Gulf of California (GC)...
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Article
Global Distribution of Halogenated Dimethyl Bipyrroles in Marine Mammal Blubber
Four halogenated dimethyl bipyrroles (HDBPs), hypothesized to be naturally produced, were quantitated in marine mammal blubber from a number of species obtained from various locations worldwide. HDBPs were fou...
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Article
In Vivo–In Vitro Correlation (IVIVC) Modeling Incorporating a Convolution Step
The purpose of in vivo–in vitro correlation (IVIVC) modeling is described. These models are usually fitted to deconvoluted data rather than the raw plasma drug concentration/time data. Such a two-stage analysi...
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Chapter
Determination of Critical Manufacturing and Formulation Variables for a Hydrophilic Matrix Tablet Formulation Using an in Vitro Discriminatory Dissolution Method
Formulation and manufacturing variables have been reported to influence the in-vitro release from hydrophilic matrix formulations. Studies on formulation and manufacturing variables have examined drug concentrati...