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  1. No Access

    Article

    Genetic variants associated with methotrexate efficacy and toxicity in early rheumatoid arthritis: results from the treatment of early aggressive rheumatoid arthritis trial

    Methotrexate (MTX) has emerged as first-line therapy for early moderate-to-severe rheumatoid arthritis (RA), but individual variation in treatment response remains unexplained. We tested the associations betwe...

    S Aslibekyan, E E Brown, R J Reynolds, D T Redden, S Morgan… in The Pharmacogenomics Journal (2014)

  2. No Access

    Article

    Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis

    Investigating genetic interactions (epistasis) has proven difficult despite the recent advances of both laboratory methods and statistical developments. With no ‘best’ statistical approach available, combining...

    F B S Briggs, P P Ramsay, E Madden, J M Norris, V M Holers, T R Mikuls… in Genes & Immunity (2010)