-
Article
Open AccessCD146 is a novel marker for highly tumorigenic cells and a potential therapeutic target in malignant rhabdoid tumor
Malignant rhabdoid tumor (MRT) is a rare, highly aggressive pediatric malignancy that primarily develops during infancy and early childhood. Despite the existing standard of intensive multimodal therapy, the p...
-
Article
PAX3-NCOA2 fusion gene has a dual role in promoting the proliferation and inhibiting the myogenic differentiation of rhabdomyosarcoma cells
We analyzed a complex chromosomal translocation in a case of embryonal rhabdomyosarcoma (RMS) and showed that it generates the fusion gene PAX3 (paired box 3)-NCOA2 (nuclear receptor coactivator 2). To understand...
-
Article
Open AccessRASSF1A hypermethylation in pretreatment serum DNA of neuroblastoma patients: a prognostic marker
The tumour suppressor gene RASSF1A is known to be frequently silenced by promoter hypermethylation in neuroblastoma tumours. Here we explored the possible prognostic significance of aberrant promoter hypermethyla...
-
Article
Open AccessMYCN gene amplification is a powerful prognostic factor even in infantile neuroblastoma detected by mass screening
MYCN is the most powerful prognostic factor in cases of older children. However, how MYCN is related to the prognosis of infantile cases is not clear. A mass screening program was carried out by measuring urinary...
-
Article
Open AccessExperience with International Neuroblastoma Staging System and Pathology Classification
The International Neuroblastoma Staging System and Pathology Classification were proposed in 1988 and in 1999, respectively, but their clinical value has not yet been fully studied in new patients. Six hundred...
