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  1. Article

    Open Access

    Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3β-Snail pathway

    Pancreatic cancer is one of the most difficult malignancies to treat owing to the rapid acquisition of resistance to chemotherapy. Gemcitabine, a first-line treatment for pancreatic cancer, prolongs patient su...

    T Namba, R Kodama, S Moritomo, T Hoshino, T Mizushima in Cell Death & Disease (2015)

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  2. Article

    Induction of EMT-like phenotypes by an active metabolite of leflunomide and its contribution to pulmonary fibrosis

    Drug-induced interstitial lung disease (ILD), particularly pulmonary fibrosis, is a serious clinical concern and myofibroblasts have been suggested to have a major role, with it recently being revealed that so...

    T Namba, K-I Tanaka, Y Ito, T Hoshino, M Matoyama… in Cell Death & Differentiation (2010)

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  3. Article

    Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis

    Apoptosis induced by nonsteroidal anti-inflammatory drugs (NSAIDs) is involved not only in the production of NSAID-induced gastric lesions but also in the antitumor activity of these drugs. The endoplasmic ret...

    S Tsutsumi, T Gotoh, W Tomisato, S Mima, T Hoshino… in Cell Death & Differentiation (2004)

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  4. No Access

    Article

    Gene expression of Bacillus subtilis subtilisin E in Thermus thermophilus

    The Bacillus subtilis subtilisin E gene was cloned into an expression vector of the extreme thermophile, Thermus thermophilus. Active subtilisin E was produced in E. coli, indicating that the Thermus promoter fun...

    H Takagi, A Suzumura, T Hoshino, S Nakamori in Journal of Industrial Microbiology and Bio… (1999)

  5. No Access

    Chapter

    Biotechnology of enzymes from cold-adapted microorganisms

    One of the main goals in enzyme research is industrial application. Nowadays, we are surrounded by enzymes as well as chemicals produced by enzymes in our daily life. Since papain (EC 3.4.22.2) was used, proba...

    S. Ohgiya, T. Hoshino, H. Okuyama, S. Tanaka… in Biotechnological Applications of Cold-Adap… (1999)

  6. No Access

    Article

    Effects of 1α-hydroxyvitamin D3 on lumbar bone mineral density and vertebral fractures in patients with postmenopausal osteoporosis

    The effects of 1α-hydroxyvitamin D3 [1α(OH)D3] on bone mineral density, fracture incidence, and bone metabolism were evaluated by a double-blind, placebo-controlled study. Eighty postmenopausal osteoporotic Japan...

    H. Orimo, M. Shiraki, Y. Hayashi, T. Hoshino, T. Onaya… in Calcified Tissue International (1994)

  7. No Access

    Article

    The effect of sulfhydryl compounds on the catalytic activity of Cu, Zn-superoxide dismutase purified from rat liver

    Sulfhydryl compounds such as reduced glutathione, cysteine and 2-mercaptopropionylglycine, a hepato-protective agent, activated Cu, Zn-superoxide dismutase purified from rat liver at low concentrations (below ...

    T. Hoshino, Y. Ohta, I. Ishiguro in Experientia (1985)

  8. No Access

    Article

    Isolation and characterization of hemagglutinins from the sponge Dysidea herbacea

    The spongeDysidea herbacea (Keller) was found to possess hemagglutinins. The major component, DHA-I, is a protein with a mol.wt of 26,000, which dissociates into subunits of equal size (14,000). It contains large...

    H. Kamiya, K. Muramoto, T. Hoshino, U. Raj in Experientia (1985)

  9. No Access

    Chapter

    Recommended Deproteinizing Methods for Plasma Guanidino Compound Analysis by Liquid Chromatography

    The quantitative determination of guanidino compounds in plasma has been performed in many laboratories working with liquid chromatography and fluorometry ; however, the obtained data were still dispersive for...

    T. Hoshino in Urea Cycle Diseases (1982)