6 Result(s)
within
Suzanne D. Vernon
Life Sciences
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Article
Open AccessAnalysis of 16S rRNA gene sequences and circulating cell-free DNA from plasma of chronic fatigue syndrome and non-fatigued subjects
The association of an infectious agent with chronic fatigue syndrome (CFS) has been difficult and is further complicated by the lack of a known lesion or diseased tissue. Cell-free plasma DNA could serve as a ...
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Article
Open AccessGene expression profile of cervical tissue compared to exfoliated cells: Impact on biomarker discovery
Exfoliated cervical cells are used in cytology-based cancer screening and may also be a source for molecular biomarkers indicative of neoplastic changes in the underlying tissue. However, because of keratiniza...
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Article
Open AccessLaboratory methods to improve SELDI peak detection and quantitation
Protein profiling with surface-enhanced laser desorption-ionisation time-of-flight mass spectrometry (SELDI-TOF MS) is a promising approach for biomarker discovery. Some candidate biomarkers have been identifi...
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Article
Open AccessA method for improving SELDI-TOF mass spectrometry data quality
Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) is a powerful tool for rapidly generating high-throughput protein profiles from a large number of samples. However, ...
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Article
Open AccessIntegrated Weighted Gene Co-expression Network Analysis with an Application to Chronic Fatigue Syndrome
Systems biologic approaches such as Weighted Gene Co-expression Network Analysis (WGCNA) can effectively integrate gene expression and trait data to identify pathways and candidate biomarkers. Here we show tha...
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Article
Open AccessCultivation of common bacterial species and strains from human skin, oral, and gut microbiota
Genomics-driven discoveries of microbial species have provided extraordinary insights into the biodiversity of human microbiota. In addition, a significant portion of genetic variation between microbiota exist...
