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Article
Open AccessA technology-enabled multi-disciplinary team-based care model for the management of Long COVID and other fatiguing illnesses within a federally qualified health center: protocol for a two-arm, single-blind, pragmatic, quality improvement professional cluster randomized controlled trial
The clinical burden of Long COVID, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and other post-infectious fatiguing illnesses (PIFI) is increasing. There is a critical need to advance understan...
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Article
Open AccessNatural killer cytotoxicity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a multi-site clinical assessment of ME/CFS (MCAM) sub-study
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystem illness characterized by substantial reduction in function accompanied by profound unexplained fatigue not significantly relieved by...
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Article
Open AccessPhysiological assessment of orthostatic intolerance in chronic fatigue syndrome
Orthostatic intolerance-OI is common in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-ME/CFS. We used a 10-min passive vertical lean test as orthostatic challenge-OC and measured changes in vitals and end...
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Article
Open AccessPrevalence of HPV infection among sexually active adolescents and young adults in Brazil: The POP-Brazil Study
For Brazil, there are no nationwide data on HPV prevalence against which the impact of the HPV immunization program can be measured in the future. Therefore, we aim to evaluate the prevalence of genital HPV in...
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Article
Open AccessUniversal human papillomavirus ty** by whole genome sequencing following target enrichment: evaluation of assay reproducibility and limit of detection
We recently described a method for unbiased detection of all known human papillomaviruses (HPV) types with the potential for the determination of their variant and integration from the resulting whole genome s...
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Article
Open AccessSimultaneous extraction of mRNA and microRNA from whole blood stabilized in tempus tubes
Studies of mRNA and miRNA expression profiling increasingly use stabilized whole blood. Commercial RNA extraction kits do not provide information about the simultaneous recovery of both mRNA and miRNA. This st...
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Article
Open AccessAssociation of chronic fatigue syndrome with premature telomere attrition
Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), is a severely debilitating condition of unknown etiology. The symptoms and risk factors of ME/CFS share features of accelerated agi...
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Article
Population-based surveillance for cervical cancer precursors in three central cancer registries, United States 2009
The USA has a well-established network of central cancer registries (CCRs) that collect data using standardized definitions and protocols to provide population-based estimates of cancer incidence. The addition...
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Article
Open AccessA pilot registry of unexplained fatiguing illnesses and chronic fatigue syndrome
Chronic fatigue syndrome (CFS) has no diagnostic clinical signs or biomarkers, so diagnosis requires ruling out conditions with similar signs and symptoms. We conducted a pilot registry of unexplained fatiguin...
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Article
Prevalence of HPV types in cervical specimens from an integrated healthcare delivery system: baseline assessment to measure HPV vaccine impact
Two human papillomavirus (HPV) vaccines are available to prevent cervical cancer. One early measure of HPV vaccine impact would be a reduction in vaccine-related HPV types (HPV 6, 11, 16, or 18, or HPV 16, 18)...
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Chapter and Conference Paper
Controlling for Population Variances in Health and Exposure Risk Using Randomized Matrix Based Mathematical Modeling
In a previous work, we analyzed the co-occurrence of HPV types in 6 large studies with cervicovaginal samples, representing >32,000 women, to ascertain if associations exist among HPV types and to guide polici...
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Article
Continuous-flow ferrohydrodynamic sorting of particles and cells in microfluidic devices
A new sorting scheme based on ferrofluid hydrodynamics (ferrohydrodynamics) was used to separate mixtures of particles and live cells simultaneously. Two species of cells, including Escherichia coli and Saccharom...
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Article
The HPV vaccine impact monitoring project (HPV-IMPACT): assessing early evidence of vaccination impact on HPV-associated cervical cancer precursor lesions
The following paper describes a collaboration between the Centers for Disease Control and Prevention and five Emerging Infections Program sites to develop a comprehensive population-based approach to monitorin...
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Article
Open AccessIdentification of Phosphoglycerate Kinase 1 (PGK1) as a reference gene for quantitative gene expression measurements in human blood RNA
Blood is a convenient sample and increasingly used for quantitative gene expression measurements with a variety of diseases including chronic fatigue syndrome (CFS). Quantitative gene expression measurements r...
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Article
Open AccessFunctional Genomics of Serotonin Receptor 2A (HTR2A): Interaction of Polymorphism, Methylation, Expression and Disease Association
Serotonergic neurotransmission plays a key role in the pathophysiology of neuropsychiatric illnesses. The functional significance of a promoter polymorphism, −1438G/A (rs6311), in one of the major genes of thi...
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Article
Open AccessImplementation of exon arrays: alternative splicing during T-cell proliferation as determined by whole genome analysis
The contribution of alternative splicing and isoform expression to cellular response is emerging as an area of considerable interest, and the newly developed exon arrays allow for systematic study of these pro...
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Article
Open AccessAssessing the relationship between HIV infection and cervical cancer in Côte d'Ivoire: A case-control study
The association between HIV infection and invasive cervical cancer that has been reported may reflect differential prevalence of human papillomavirus (HPV) infection or uncontrolled confounding. We conducted a...
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Article
Open AccessCharacterization of the Human Cervical Mucous Proteome
Cervical cancer is among the most common cancers in women worldwide. Discovery of biomarkers for the early detection of cervical cancer would improve current screening practices and reduce the burden of disease.
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Article
Open AccessAn evaluation of exclusionary medical/psychiatric conditions in the definition of chronic fatigue syndrome
The diagnosis of chronic fatigue syndrome (CFS) in research studies requires the exclusion of subjects with medical and psychiatric conditions that could confound the analysis and interpretation of results. Th...
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Article
Open AccessPerception versus polysomnographic assessment of sleep in CFS and non-fatigued control subjects: results from a population-based study
Complaints of unrefreshing sleep are a prominent component of chronic fatigue syndrome (CFS); yet, polysomnographic studies have not consistently documented sleep abnormalities in CFS patients. We conducted th...
