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Article
Open AccessA deep catalogue of protein-coding variation in 983,578 individuals
Rare coding variants that substantially affect function provide insights into the biology of a gene1–3. However, ascertaining the frequency of such variants requires large sample sizes4–8. Here we present a catal...
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Article
Open AccessRare coding variants in CHRNB2 reduce the likelihood of smoking
Human genetic studies of smoking behavior have been thus far largely limited to common variants. Studying rare coding variants has the potential to identify drug targets. We performed an exome-wide association...
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Article
Stage-specific requirement for Mettl3-dependent m6A mRNA methylation during haematopoietic stem cell differentiation
Haematopoietic stem cells (HSCs) maintain balanced self-renewal and differentiation, but how these functions are precisely regulated is not fully understood. N6-methyladenosine (m6A) messenger RNA methylation has...
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Article
Integrated analysis of mRNA-seq and miRNA-seq for host susceptibilities to influenza A (H7N9) infection in inbred mouse lines
Host genetic factors play an important role in diverse host outcomes after influenza A (H7N9) infection. Studying differential responses of inbred mouse lines with distinct genetic backgrounds to influenza vir...
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Article
Open AccessPrioritizing genes responsible for host resistance to influenza using network approaches
The genetic make-up of humans and other mammals (such as mice) affects their resistance to influenza virus infection. Considering the complexity and moral issues associated with experiments on human subjects, ...
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Protocol
Short Read Map** for Exome Sequencing
Map** short reads to the reference genome is very often the prerequisite for applications utilizing the next-generation sequencing technologies. A dozen of software tools developed for this purpose have been...
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Article
Evaluation of next-generation sequencing software in map** and assembly
Next-generation high-throughput DNA sequencing technologies have advanced progressively in sequence-based genomic research and novel biological applications with the promise of sequencing DNA at unprecedented ...
