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  1. No Access

    Chapter

    Marine Materials: Gene Delivery

    The hurdle in the gene therapy is a lack of suitable gene carrier although animal virus vectors have been mostly used in vivo and in clinical applications due to their high transfection efficiency. However, th...

    Bijay Singh, Sushila Maharjan, Yun-Jaie Choi… in Springer Handbook of Marine Biotechnology (2015)

  2. No Access

    Article

    Metabolic Engineering of Nocardia sp. CS682 for Enhanced Production of Nargenicin A1

    A number of secondary metabolites having therapeutic importance have been reported from the genus Nocardia. One of the polyketide antibiotic compounds isolated from Nocardia is nargenicin A1. Recently, nargenicin...

    Sushila Maharjan, Dinesh Koju, Hei Chan Lee… in Applied Biochemistry and Biotechnology (2012)

  3. No Access

    Article

    Biosynthesis of the nargenicin A1 pyrrole moiety from Nocardia sp. CS682

    A number of structurally diverse natural products harboring pyrrole moieties possess a wide range of biological activities. Studies on biosynthesis of pyrrole ring have shown that pyrrole moieties are derived ...

    Sushila Maharjan, Niraj Aryal, Saurabh Bhattarai… in Applied Microbiology and Biotechnology (2012)

  4. No Access

    Article

    Metabolic engineering of Streptomyces venezuelae for malonyl-CoA biosynthesis to enhance heterologous production of polyketides

    Using metabolic engineering, we developed Streptomyces venezuelae YJ028 as an efficient heterologous host to increase the malonyl-CoA pool to be directed towards enhanced production of various polyketides. To pro...

    Sushila Maharjan, Je Won Park, Yeo Joon Yoon, Hei Chan Lee… in Biotechnology Letters (2010)

  5. No Access

    Article

    Heterologous expression of metK1-sp and afsR-sp in Streptomyces venezuelae for the production of pikromycin

    Two regulator genes, metK1-sp and afsR-sp, from Streptomyces peucetius ATCC 27952 were heterologously expressed in S. venezuelae ATCC 15439, to produce 14-membered pikromycin antibiotics. The production of pikrom...

    Sushila Maharjan, Tae-** Oh, Hei Chan Lee, Jae Kyung Sohng in Biotechnology Letters (2008)