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Chapter
Marine Materials: Gene Delivery
The hurdle in the gene therapy is a lack of suitable gene carrier although animal virus vectors have been mostly used in vivo and in clinical applications due to their high transfection efficiency. However, th...
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Article
Metabolic Engineering of Nocardia sp. CS682 for Enhanced Production of Nargenicin A1
A number of secondary metabolites having therapeutic importance have been reported from the genus Nocardia. One of the polyketide antibiotic compounds isolated from Nocardia is nargenicin A1. Recently, nargenicin...
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Article
Metabolic engineering of Streptomyces venezuelae for malonyl-CoA biosynthesis to enhance heterologous production of polyketides
Using metabolic engineering, we developed Streptomyces venezuelae YJ028 as an efficient heterologous host to increase the malonyl-CoA pool to be directed towards enhanced production of various polyketides. To pro...
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Article
Heterologous expression of metK1-sp and afsR-sp in Streptomyces venezuelae for the production of pikromycin
Two regulator genes, metK1-sp and afsR-sp, from Streptomyces peucetius ATCC 27952 were heterologously expressed in S. venezuelae ATCC 15439, to produce 14-membered pikromycin antibiotics. The production of pikrom...