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Article
Open AccessIs physical restraint unethical and illegal?: a qualitative analysis of Korean written judgments
Physical restraint (PR) is used to ensure the safety of care recipients. However, this causes an ethical dilemma between the autonomy and dignity of the recipients and the provision of effective treatment by h...
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Article
Open AccessEvaluation of penalized and machine learning methods for asthma disease prediction in the Korean Genome and Epidemiology Study (KoGES)
Genome-wide association studies have successfully identified genetic variants associated with human disease. Various statistical approaches based on penalized and machine learning methods have recently been pr...
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Article
Open AccessDrug response prediction model using a hierarchical structural component modeling method
Component-based structural equation modeling methods are now widely used in science, business, education, and other fields. This method uses unobservable variables, i.e., “latent” variables, and structural equ...
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Article
Open AccessPathway-based approach using hierarchical components of rare variants to analyze multiple phenotypes
As one possible solution to the “missing heritability” problem, many methods have been proposed that apply pathway-based analyses, using rare variants that are detected by next generation sequencing technology...
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Article
Open AccessHierarchical structural component modeling of microRNA-mRNA integration analysis
Identification of multi-markers is one of the most challenging issues in personalized medicine era. Nowadays, many different types of omics data are generated from the same subject. Although many methods endea...
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Article
Open AccessWISARD: workbench for integrated superfast association studies for related datasets
A Mendelian transmission produces phenotypic and genetic relatedness between family members, giving family-based analytical methods an important role in genetic epidemiological studies—from heritability estima...
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Article
Open AccessComparing family-based rare variant association tests for dichotomous phenotypes
It has been repeatedly stressed that family-based samples suffer less from genetic heterogeneity and that association analyses with family-based samples are expected to be powerful for detecting susceptibility...
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Article
Robust analysis with related samples under the presence of population substructure and its application to body mass index
Recent investigations such as a more powerful quasi-likelihoods score test (MQLS) statistic have enabled the efficient association analysis with related samples. Although those approaches are robust against th...
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Article
Fine-scale map** of disease susceptibility locus with Bayesian partition model
The causal relationship between genes and diseases has been investigated with the development of DNA sequence. Polymorphisms incorporated in the HapMap Project have enabled fine map** with linkage disequilib...
