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Article
Behavioral and transcriptional effects of repeated electroconvulsive seizures in the neonatal MK-801-treated rat model of schizophrenia
Electroconvulsive therapy (ECT) is an effective treatment modality for schizophrenia. However, its antipsychotic-like mechanism remains unclear.
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Article
Open AccessGut microbiome signature of metabolically healthy obese individuals according to anthropometric, metabolic and inflammatory parameters
In this study, we investigated the characteristics of gut microbiome in the metabolically healthy obese (MHO) patients, and how they correlate with metabolic and inflammatory profiles. A total of 120 obese peo...
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Article
Open AccessGenome-wide association study implicates the role of TBXAS1 in the pathogenesis of depressive symptoms among the Korean population
Although depression is an emerging disorder affecting many people worldwide, most genetic studies have been performed in European descent populations. Herein, a genome-wide association study (GWAS) was conduct...
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Article
Open AccessComparative analysis of batch correction methods for FDG PET/CT using metabolic radiogenomic data of lung cancer patients
In radiomics research, the issue of different instruments being used is significant. In this study, we compared three correction methods to reduce the batch effects in radiogenomic data from fluorodeoxyglucose...
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Article
Open AccessIdentification of asthma-related genes using asthmatic blood eQTLs of Korean patients
More than 200 asthma-associated genetic variants have been identified in genome-wide association studies (GWASs). Expression quantitative trait loci (eQTL) data resources can help identify causal genes of the ...
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Article
Open AccessAutomating Rey Complex Figure Test scoring using a deep learning-based approach: a potential large-scale screening tool for cognitive decline
The Rey Complex Figure Test (RCFT) has been widely used to evaluate the neurocognitive functions in various clinical groups with a broad range of ages. However, despite its usefulness, the scoring method is as...
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Article
Open AccessLongitudinal mortality of preserved ratio impaired spirometry in a middle-aged Asian cohort
Although preserved ratio impaired spirometry (PRISm) has been determined to have poor prognosis, it is a heterogeneous state, and studies regarding its prognosis in Asians are limited. This study investigated ...
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Article
Serious infections and tuberculosis in psoriasis patients receiving systemic therapy in Korea: a nationwide population-based cohort study
Psoriasis itself, as well as its immunomodulatory drugs, may alter the immune system, increasing the risk of infections. Recent research has indicated that patients with psoriasis are at an increased risk of d...
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Article
Open AccessPrenatal phthalate exposure and cord blood DNA methylation
Exposure to phthalates has been shown to impede the human endocrine system, resulting in deleterious effects on pregnant women and their children. Phthalates modify DNA methylation patterns in infant cord bloo...
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Article
Rex: R-linked EXcel add-in for statistical analysis of medical and bioinformatics data
Microsoft Excel has substantial functionalities for data management and analyses, and has been the most popular software in this field. However, in spite of Excel’s user-friendly interface and functionality fo...
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Article
Open AccessLongitudinal association between adiposity changes and lung function deterioration
The longitudinal relationship between adiposity and lung function is controversial. We aimed to investigate the long-term association between adiposity changes and lung function in a middle-aged general Asian ...
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Article
Open AccessIdentification of genetic variants associated with diabetic kidney disease in multiple Korean cohorts via a genome-wide association study mega-analysis
The pathogenesis of diabetic kidney disease (DKD) is complex, involving metabolic and hemodynamic factors. Although DKD has been established as a heritable disorder and several genetic studies have been conduc...
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Article
Open AccessA genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD
Asthma and chronic obstructive pulmonary disease (COPD) are two distinct diseases that are associated with chronic inflammation. They share common features in terms of their advanced stages and genetic factors...
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Article
Open AccessRisk of malignancy in patients with psoriasis according to treatment modalities in Korea: a nationwide cohort study
Intrinsic immunologic disparity of psoriasis itself, along with chronic inflammation and immunomodulatory anti-psoriatic treatments could be associated with increased risk of malignancy. We aimed to estimate t...
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Article
Relative contributions of the host genome, microbiome, and environment to the metabolic profile
Metabolic syndrome is as a well-known risk factor for cardiovascular disease, which is associated with both genetic and environmental factors. Recently, the microbiome composition has been shown to affect the ...
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Article
Open AccessRole of an unclassified Lachnospiraceae in the pathogenesis of type 2 diabetes: a longitudinal study of the urine microbiome and metabolites
Recent investigations have revealed that the human microbiome plays an essential role in the occurrence of type 2 diabetes (T2D). However, despite the importance of understanding the involvement of the microbi...
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Article
Open AccessLaboratory information management system for COVID-19 non-clinical efficacy trial data
As the number of large-scale studies involving multiple organizations producing data has steadily increased, an integrated system for a common interoperable format is needed. In response to the coronavirus dis...
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Article
missForest with feature selection using binary particle swarm optimization improves the imputation accuracy of continuous data
Missing data are a common problem in large-scale datasets and its appropriate handling is crucial for data analyses. Missingness can be categorized as (1) missing completely at random (MCAR), (2) missing at ra...
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Article
rs2671655 single nucleotide polymorphism modulates the risk for gastric cancer in Helicobacter pylori–infected individuals: a genome-wide association study in the Korean population
To identify genetic variations which is associated with gastric cancer (GC) risk according to Helicobacter pylori infection.
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Article
Open AccessUnveiling genetic variants for age-related sarcopenia by conducting a genome-wide association study on Korean cohorts
Sarcopenia is an age-related disorder characterised by a progressive decrease in skeletal muscle mass. As the genetic biomarkers for sarcopenia are not yet well characterised, this study aimed to investigate t...
