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Article
Open AccessAltered gut microbiota in Taiwanese A97S predominant transthyretin amyloidosis with polyneuropathy
Increasing evidence suggests that gut microbiota alterations are related to development and phenotypes of many neuropsychiatric diseases. Here, we evaluated the fecal microbiota and its clinical correlates in ...
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Article
Open AccessNME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia
NME3 is a member of the nucleoside diphosphate kinase (NDPK) family localized on the mitochondrial outer membrane (MOM). Here, we report a role of NME3 in hypoxia-induced mitophagy dependent on its active site...
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Article
HSP27 Modulates Neuropathic Pain by Inhibiting P2X3 Degradation
The role of heat shock protein 27 (HSP27), a chaperone, in neuropathic pain after nerve injury has not been systematically surveyed despite its neuroprotective and regeneration-promoting effects. In this study...
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Article
Open AccessDental Pulp Stem Cell-Derived Conditioned Medium Alleviates Subarachnoid Hemorrhage-Induced Microcirculation Impairment by Promoting M2 Microglia Polarization and Reducing Astrocyte Swelling
Aneurysmal subarachnoid hemorrhage (SAH) can cause severe neurological deficits and high mortality. Early brain edema following SAH contributes to the initiation of microcirculation impairment and may further ...
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Article
Open AccessTafamidis decreased cardiac amyloidosis deposition in patients with Ala97Ser hereditary transthyretin cardiomyopathy: a 12-month follow-up cohort study
Transthyretin cardiac cardiomyopathy (ATTR-CM) is a rare but life-threatening disease. Tafamidis is an effective treatment for patients with ATTR-CM, however its long-term effects on cardiac remodeling and car...
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Article
Open AccessRU-Net: skull strip** in rat brain MR images after ischemic stroke with rat U-Net
Experimental ischemic stroke models play a fundamental role in interpreting the mechanism of cerebral ischemia and appraising the development of pathological extent. An accurate and automatic skull strip** t...
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Article
Open AccessCombination of indirect revascularization and endothelial progenitor cell transplantation improved cerebral perfusion and ameliorated tauopathy in a rat model of bilateral ICA ligation
Endothelial progenitor cells (EPCs) contribute to the recovery of neurological function after ischemic stroke. Indirect revascularization has exhibited promising effects in the treatment of cerebral ischemia r...
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Article
Neuroprotective Effects of a Cardioplegic Combination (Adenosine, Lidocaine, and Magnesium) in an Ischemic Stroke Model
Adenosine, lidocaine, and magnesium (ALM) are clinically available cardioplegic solutions. We examined the effects of low-dose ALM on ischemic stroke in cell and animal models. Cobalt chloride (CoCl2)–treated SH-...
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Article
Open AccessMitochondrial DNA methylation profiling of the human prefrontal cortex and nucleus accumbens: correlations with aging and drug use
Despite the brain’s high demand for energy, research on its epigenetics focuses on nuclear methylation, and much of the mitochondrial DNA methylation remains seldom investigated. With a focus on the nucleus ac...
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Article
Open AccessCirculating Diabetic Candidate Neurotrophic Factors, Brain-Derived Neurotrophic Factor and Fibroblast Growth Factor 21, in Sleeve Gastrectomy
Recent studies show brain-derived neurotrophic factor (BDNF) and fibroblast growth factor 21 (FGF21) are neurotrophic factors associated with obesity and diabetes mellitus (DM). Laparoscopic sleeve gastrectomy...
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Article
Open AccessFibronectin inhibitor pUR4 attenuates tumor necrosis factor α–induced endothelial hyperpermeability by modulating β1 integrin activation
The blood–spinal cord barrier (BSCB) is composed of a monolayer of endothelium linked with tight junctions and extracellular matrix (ECM)-rich basement membranes and is surrounded by astrocyte foot processes. ...
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Chapter
Overview of Small Fiber Neuropathy
Small fiber neuropathy (SFN) results from impairment of small-diameter myelinated Aδ- and unmyelinated C-fibers. This debilitating condition usually leads to alterations in nociceptive processing, thermal sens...
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Chapter
Small Fiber Pathology and Functional Impairment in Syndromes of Predominantly Large Fiber Neuropathy
In peripheral neuropathies with sensory ataxia or weakness of distal limbs, traditionally nerve conduction studies are the first-line tests, and these neuropathies are classified as large fiber neuropathy incl...
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Chapter
Neuropathic Pain in Small Fiber Neuropathy
Neuropathic pain is the most common and disabling symptom in small fiber neuropathy (SFN). It usually presents as a burning or tingling sensation in the distal limbs, accompanied by increased pain sensitivity,...
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Chapter
Amyloid Neuropathy
Amyloid neuropathy is a syndrome of peripheral nerve degeneration associated with deposition of amyloid attributed to various molecular compositions including (1) monoclonal protein of immunoglobulin light cha...
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Article
Open AccessImpaired microcirculation after subarachnoid hemorrhage in an in vivo animal model
The influence of aneurysmal subarachnoid hemorrhage (SAH) on brain microcirculation has not yet been systematically investigated. We established an animal model to examine (1) the brain surface microcirculatio...
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Article
Nerve Decompression Improves Spinal Synaptic Plasticity of Opioid Receptors for Pain Relief
Nerve decompression is an essential therapeutic strategy for pain relief clinically; however, its potential mechanism remains poorly understood. Opioid analgesics acting on opioid receptors (OR) within the var...
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Article
Open AccessAttenuated contact heat-evoked potentials associated with sensory and social-emotional symptoms in individuals with autism spectrum disorder
Sensory disturbance is associated with socio-emotional problems in individuals with autism spectrum disorder (ASD). Most studies assess sensory symptoms by self-reports, which are largely limited by the langua...
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Article
Open AccessEffective gene expression in the rat dorsal root ganglia with a non-viral vector delivered via spinal nerve injection
Delivering gene constructs into the dorsal root ganglia (DRG) is a powerful but challenging therapeutic strategy for sensory disorders affecting the DRG and their peripheral processes. The current delivery met...
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Article
Open AccessQuality of life in polyneuropathy: association with biomarkers of small fiber impairment
Polyneuropathy presumably lowers quality of life (QoL). However, there is a lack of systematic studies that assess QoL changes and biomarkers of polyneuropathy as determinants of QoL. We aimed to investigate t...
