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Article
Open AccessVU0155069 inhibits inflammasome activation independent of phospholipase D1 activity
The inflammasome is a specialized multiprotein oligomer that regulates IL-1β production. Although regulation of the inflammasome is related to crucial inflammatory disorders such as sepsis, pharmacological inh...
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Article
Open AccessA phospholipase D2 inhibitor, CAY10594, ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis
We examined the role of phospholipase D2 (PLD2) on acetaminophen (APAP)-induced acute liver injury using a PLD2 inhibitor (CAY10594). 500 mg/kg of APAP challenge caused acute liver damage. CAY10594 administrat...
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Article
Open AccessLysophosphatidic acid protects against acetaminophen-induced acute liver injury
We investigated the effect of lysophosphatidic acid (LPA) in experimental acetaminophen (APAP)-induced acute liver injury. LPA administration significantly reduced APAP-challenged acute liver injury, showing a...
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Article
Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6
Transforming growth factor (TGF)-β, a pivotal cytokine involved in a variety of cellular functions, transmits signals through Smad-dependent canonical and Smad-independent noncanonical pathways. In contrast to...
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Article
Open AccessThe immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis
In this study, we examined the therapeutic effects of an immune-stimulating peptide, WKYMVm, in ulcerative colitis. The administration of WKYMVm to dextran sodium sulfate (DSS)-treated mice reversed decreases ...
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Article
Open AccessSol–gel derived ferroelectric Bi3.15Nd0.85Ti3O12 thin films of predominant 100/010/119 orientation deposited both on Nb-doped (011)SrTiO3 and on (011)SrRuO3/(011)SrTiO3
Ferroelectric Bi3.15Nd0.85Ti3O12 (BNdT) thin films of predominant 100/010/119 orientation were grown through a cheap and simple sol–gel process both on Nb-doped (011)SrTiO3 and on (011)SrRuO3/(011)SrTiO3. Using r...
