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Article
Open AccessDistinct effects of cholesterol profile components on amyloid and vascular burdens
Cholesterol plays important roles in β-amyloid (Aβ) metabolism and atherosclerosis. However, the relationships of plasma cholesterol levels with Aβ and cerebral small vessel disease (CSVD) burdens are not full...
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Article
Open AccessIndependent effect of Aβ burden on cognitive impairment in patients with small subcortical infarction
The effect of amyloid-β (Aβ) on cognitive impairment in patients with small subcortical infarction remains controversial, although a growing body of evidence shows a substantial overlap between Alzheimer’s dis...
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Article
Open AccessDifferent effects of cardiometabolic syndrome on brain age in relation to gender and ethnicity
A growing body of evidence shows differences in the prevalence of cardiometabolic syndrome (CMS) and dementia based on gender and ethnicity. However, there is a paucity of information about ethnic- and gender-...
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Article
Open AccessGender-specific relationship between thigh muscle and fat mass and brain amyloid-β positivity
The relationship of specific body composition in the thighs and brain amyloid-beta (Aβ) deposition remained unclear, although there were growing evidence that higher muscle and fat mass in thighs had a protect...
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Article
Open AccessDecreased visual acuity is related to thinner cortex in cognitively normal adults: cross-sectional, single-center cohort study
Decreased visual acuity (VA) is reported to be a risk factor for dementia. However, the association between VA and cortical thickness has not been established. We investigated the association between VA and co...
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Article
Open AccessIdentifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population
Genome-wide association studies (GWAS) have identified a number of genetic variants for Alzheimer’s disease (AD). However, most GWAS were conducted in individuals of European ancestry, and non-European populat...
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Article
Open AccessDifferential effects of risk factors on the cognitive trajectory of early- and late-onset Alzheimer’s disease
Although few studies have shown that risk factors for Alzheimer’s disease (AD) are associated with cognitive decline in AD, not much is known whether the impact of risk factors differs between early-onset AD (...
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Article
Open AccessCognitive trajectories of patients with focal ß-amyloid deposition
The presence of ß-amyloid (Aß) in the brain can be identified using amyloid PET. In clinical practice, the amyloid PET is interpreted based on dichotomous visual rating, which renders focal Aß accumulation be ...
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Article
Open AccessOptical coherence tomography angiography as a potential screening tool for cerebral small vessel diseases
The retina and the brain share anatomic, embryologic, and physiologic characteristics. Therefore, retinal imaging in patients with brain disorders has been of significant interest. Using optical coherence tomo...