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Article
Open AccessThrombopoietin receptor agonist antibody for treating chemotherapy-induced thrombocytopenia
Thrombocytopenia is a common complication in cancer patients undergoing chemotherapy. Chemotherapy-induced thrombocytopenia (CIT) leads to dose reduction and treatment delays, lowering chemotherapy efficacy an...
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Article
Open AccessCLEC14a-HSP70-1A interaction regulates HSP70-1A-induced angiogenesis
CLEC14a (C-type lectin domain family 14 member) is a tumor endothelial cell marker protein that is known to play an important role in tumor angiogenesis, but the basic molecular mechanisms underlying this func...
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Article
Open AccessIg-like domain 6 of VCAM-1 is a potential therapeutic target in TNFα-induced angiogenesis
Tumor necrosis factor alpha (TNFα)-induced angiogenesis plays important roles in the progression of various diseases, including cancer, wet age-related macular degeneration, and rheumatoid arthritis. However, ...
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Article
Open AccessAdaptor Protein 2 (AP-2) complex is essential for functional axogenesis in hippocampal neurons
The complexity and diversity of a neural network requires regulated elongation and branching of axons, as well as the formation of synapses between neurons. In the present study we explore the role of AP-2, a ...
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Article
Lysophosphatidic acid signaling through LPA receptor subtype 1 induces colony scattering of gastrointestinal cancer cells
Lysophosphatidic acid (LPA) is a multifunctional lipid mediator involved in triggering tumor cell invasion and metastasis, as well as malignant cell growth. LPA is also known to modulate the colony scattering ...
