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Article
Open AccessCREB5 promotes the proliferation and self-renewal ability of glioma stem cells
Glioblastoma multiforme (GBM) is the most fatal form of brain cancer in humans, with a dismal prognosis and a median overall survival rate of less than 15 months upon diagnosis. Glioma stem cells (GSCs), have ...
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Article
Open AccessDevelo** a diagnosis model for dry eye disease in dogs using object detection
The purpose of this study was to develop an object detection method for the diagnosis of dry eye disease (DED) in dogs. To this end, a methodology was designed to evaluate ocular surface video images using the...
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Article
Open AccessAuthor Correction: Automated severity scoring of atopic dermatitis patients by a deep neural network
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Article
Open AccessAutomated severity scoring of atopic dermatitis patients by a deep neural network
Scoring atopic dermatitis (AD) severity with the Eczema Area and Severity Index (EASI) in an objective and reproducible manner is challenging. Automated measurement of erythema, papulation, excoriation, and li...
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Article
Open AccessSynchrotron radiation imaging analysis of neural damage in mouse soleus muscle
Damage to lower limb muscles requires accurate analysis of the muscular condition via objective microscopic diagnosis. However, microscopic tissue analysis may cause deformation of the tissue structure due to ...
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Article
Open AccessCNN-based diagnosis models for canine ulcerative keratitis
The purpose of this methodological study was to develop a convolutional neural network (CNN), which is a recently developed deep-learning-based image recognition method, to determine corneal ulcer severity in ...
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Article
Open AccessPhc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression
The timely mobilization of hematopoietic stem and progenitor cells (HSPCs) is essential for maintaining hematopoietic and tissue leukocyte homeostasis. Understanding how HSPCs migrate between bone marrow (BM) ...
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Article
The Inter/Intra-brain Metabolite Concentration Change as Applying the Rehabilitate Treatment in Intra-cerebral Hemorrhage Rat Models: Pilot Study
If intra-cerebral hemorrhage (ICH) rehabilitation animal model studies had included processes related to imaging diagnosis, not only interim evaluation of treatment effects but also the objectification of trea...
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Article
Open AccessEvaluation of relationships between onychomycosis and vascular diseases using sequential pattern mining
Onychomycosis (OM) is a common nail disease. Although controversial, vascular diseases are considered independent predictors of OM and vice versa. Sequential pattern mining (SPM) has not been previously used f...
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Article
Pig tissue factor pathway inhibitor α fusion immunoglobulin inhibits pig tissue factor activity in human plasma moderately more efficiently than the human counterpart
To determine the efficacy of soluble pig tissue factor pathway inhibitor fusion immunoglobulin (TFPI-Ig) in blocking pig to human xenogeneic blood coagulation.
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Article
The image evaluation of iterative motion correction reconstruction algorithm PROPELLER T2-weighted imaging compared with MultiVane T2-weighted imaging
The purpose of this study was to evaluate the usefulness and clinical applications of MultiVaneXD which was applying iterative motion correction reconstruction algorithm T2-weighted images compared with MultiV...
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Article
The Medical 1H-MRS Analysis of Edible Vegetable Oils Rancidity: Focus on the Saturated/Unsaturated Fatty Acids (Bond) Change
The purpose of this study was to investigate the usefulness of medical magnetic resonance spectroscopy analysis methods for assessment of edible oil rancidity. The four edible oils including soybean oil, olive...
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Article
Effectiveness Evaluation of the Fat Percentage Determination in Multi-Echo T2-Corrected Single-Voxel Spectroscopy by Comparing the 3-Point Dixon and the 6-Point Interference Dixon Techniques
This study compared fat percentage in the HISTO method and chemical-shift imaging method, a 3-echo 3D gradient echo sequence with a T2*-corrected Dixon (3-point Dixon) and 6-echo interference Dixon magnetic re...
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Article
Assessment of the evaluation of liver T1 map** imaging applying virtual ECG gating on a modified look-locker inversion recovery (MOLLI) pulse sequence
A T1 map** calculation error may occur in a physicochemical environment with large relaxivity. We evaluated through a simulated electrocardiogram (ECG) the administration of a contrast with high relaxivity a...
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Article
Human cytomegalovirus (HCMV) US2 protein interacts with human CD1d (hCD1d) and down-regulates invariant NKT (iNKT) cell activity
To avoid host immune surveillance, human cytomegalovirus (HCMV) encoded endoplasmic reticulum (ER)-membrane glycoprotein US2, which interferes with antigen presenting mechanism of Major histocompatibility comp...
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Article
Expression pattern and functional role of Phc2 during activation of helper T cells after antigenic stimulation
Polycomb group (PcG) proteins, which are conserved from invertebrates to mammals, are associated with epigenetic regulation of many cell fates. The activities of PcG proteins are largely associated with modula...
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Article
Saponins from soy bean and mung bean inhibit the antigen specific activation of helper T cells by blocking cell cycle progression
Treatment of helper T (Th) cells with saponins from soy bean and mung bean prevented their activation by inhibiting cell proliferation and cytokine secretion. However, the saponins did not affect the expressio...
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Article
Generation and evaluation of the efficacy of rhesus monkey soluble cytotoxic T lymphocyte-associated antigen-4 in the allogeneic mixed lymphocyte reaction
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4; CD152) is a transmembrane protein that is structurally similar to CD28. As CTLA-4 has a much higher binding affinity to B7 than CD28, several approaches usi...
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Article
Porcine testicular extract inhibits T cell proliferation by blocking cell cycle transition from G1 phase to S phase
Since T cells express diverse sex steroid hormone receptors, they might be a good model to evaluate the effects of sex steroid hormones on immune modulation. Porcine testicular extract contains several sex ste...
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Article
E6 and E7 fusion immunoglobulin from human papilloma virus 16 induces dendritic cell maturation and antigen specific activation of T helper 1 response
Human papilloma virus (HPV) 16 causes cervical cancer. Induction of oncogenesis by HPV 16 is primarily dependent on the function of E6 and E7 proteins, which inactivate the function of p53 and pRB, respectivel...
