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Open AccessMultiplatform molecular profiling uncovers two subgroups of malignant peripheral nerve sheath tumors with distinct therapeutic vulnerabilities
Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive sarcoma, and a lethal neurofibromatosis type 1-related malignancy, with little progress made on treatment strategies. Here, we apply a mul...
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Article
Open AccessMultiplatform molecular analysis of vestibular schwannoma reveals two robust subgroups with distinct microenvironment
Vestibular schwannoma (VS) is the most common tumour of the cerebellopontine angle and poses a significant morbidity for patients. While many exhibit benign behaviour, others have a more aggressive nature and ...
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Cranial Nerve Tumors
Neoplasms arising from the cranial nerves (CNs) often lead to significant morbidity and impairment of quality of life through functional disruption of the CN of origin, as well as adjacent CNs. A multidiscipli...
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Article
Bullseye EVD: preclinical evaluation of an intra-procedural system to confirm external ventricular drainage catheter positioning
External ventricular drainage (EVD) is a life-saving procedure indicated for elevated intracranial pressure. A catheter is inserted into the ventricles to drain cerebrospinal fluid and release the pressure on ...
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Article
Current state of therapeutic focused ultrasound applications in neuro-oncology
Despite manifold advances in oncology, cancers of the central nervous system remain among the most lethal. Unique features of the brain, including distinct cellular composition, immunological privilege, and ph...
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Article
A clinically applicable integrative molecular classification of meningiomas
Meningiomas are the most common primary intracranial tumour in adults1. Patients with symptoms are generally treated with surgery as there are no effective medical therapies. The World Health Organization histopa...
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Correction to: Epigenomic, genomic, and transcriptomic landscape of schwannomatosis
In the original publication, corresponding author information missed indicating that Dr. Zadeh.
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Open AccessEpigenomic, genomic, and transcriptomic landscape of schwannomatosis
Schwannomatosis (SWNTS) is a genetic cancer predisposition syndrome that manifests as multiple and often painful neuronal tumors called schwannomas (SWNs). While germline mutations in SMARCB1 or LZTR1, plus somat...
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Open AccessProgrammed death ligand-1 (PD-L1) expression in meningioma; prognostic significance and its association with hypoxia and NFKB2 expression
Management of clinically aggressive meningiomas is a considerable challenge. PD-L1 induced immune suppression has increasingly gained attention in clinical management of cancer; however, to date, the clinical ...
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Open AccessThe central nervous system tumor methylation classifier changes neuro-oncology practice for challenging brain tumor diagnoses and directly impacts patient care
Molecular signatures are being increasingly incorporated into cancer classification systems. DNA methylation-based central nervous system (CNS) tumor classification is being recognized as having the potential ...
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Peripheral Nerve Sheath Tumors
Peripheral nerve sheath tumors (PNST) are a relatively uncommon soft tissue neoplasm that can arise from anywhere on the body and range from benign tumors, such as schwannomas and cutaneous neurofibromas, to h...
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Open AccessCurrent and emerging brain applications of MR-guided focused ultrasound
MRI guided focused ultrasound is an emerging technique that uses acoustic energy to noninvasively treat intracranial disorders. At high frequencies, it can be used to raise tissue temperatures and ablate discr...
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Open AccessTherapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas
Cranial radiotherapy improves survival of the most common childhood cancers, including brain tumors and leukemia. Unfortunately, long-term survivors are faced with consequences of secondary neoplasia, includin...
