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Protocol
Fluorescence Spectroscopy: A Useful Method to Explore the Interactions of Small Molecule Ligands with DNA Structures
Small molecule ligands-DNA interactions have recently received a lot of attention in the fields of life sciences, medicine, and chemical sciences. To decode these interactions, many strategies have been develo...
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Article
Open AccessTheranostic approach to specifically targeting the interloop region of BCL2 i-motif DNA by crystal violet
Ligands that recognise specific i-motif DNAs are helpful in cancer diagnostics and therapeutics, as i-motif formation can cause cancer. Although the loop regions of i-motifs are promising targets for ligands, ...
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Article
Open AccessPreferential targeting cancer-related i-motif DNAs by the plant flavonol fisetin for theranostics applications
The relationship of i-motif DNAs with cancer has prompted the development of specific ligands to detect and regulate their formation. Some plant flavonols show unique fluorescence and anti-cancer properties, w...
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Article
9-Phenyl acridine exhibits antitumour activity by inducing apoptosis in A375 cells
Several acridine derivatives have been screened for their therapeutic potential and some are already established as antiprotozoan, antibacterial or anticancer agents. However, phenyl derivative at C-9 position...
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Article
Chemotherapeutic potential of 9-phenyl acridine: biophysical studies on its binding to DNA
Acridines and their derivatives are well-known probes for nucleic acids as well as being relevant in the field of drug development to establish new chemotherapeutic agents. We have shown from molecular modelli...
