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Article
Open AccessTheranostic approach to specifically targeting the interloop region of BCL2 i-motif DNA by crystal violet
Ligands that recognise specific i-motif DNAs are helpful in cancer diagnostics and therapeutics, as i-motif formation can cause cancer. Although the loop regions of i-motifs are promising targets for ligands, ...
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Reference Work Entry In depth
Stability Prediction of Canonical and Noncanonical Structures of Nucleic Acids
The folding and unfolding of nucleic acids (DNA and RNA) is essential for cellular functions. These structural changes in nucleic acids are also widely used in various technical applications using nucleic acid...
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Article
Open AccessTriglyceride-glucose index as a prognostic marker after ischemic stroke or transient ischemic attack: a prospective observational study
Triglyceride-glucose (TyG) index has been proposed as a simple and credible surrogate for insulin resistance and an independent predictor of cardiovascular outcomes. Due to lack of data on TyG index in stroke,...
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Article
Open AccessDielectricity of a molecularly crowded solution accelerates NTP misincorporation during RNA-dependent RNA polymerization by T7 RNA polymerase
In biological systems, the synthesis of nucleic acids, such as DNA and RNA, is catalyzed by enzymes in various aqueous solutions. However, substrate specificity is derived from the chemical properties of the r...
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Living Reference Work Entry In depth
Stability Prediction of Canonical and Noncanonical Structures of Nucleic Acids
The folding and unfolding of nucleic acids (DNA and RNA) is essential for cellular functions. These structural changes in nucleic acids are also widely used in various technical applications using nucleic acid...
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Article
Open AccessPreferential targeting cancer-related i-motif DNAs by the plant flavonol fisetin for theranostics applications
The relationship of i-motif DNAs with cancer has prompted the development of specific ligands to detect and regulate their formation. Some plant flavonols show unique fluorescence and anti-cancer properties, w...
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Protocol
Quantitative Analysis of Stall of Replicating DNA Polymerase by G-Quadruplex Formation
The formation of guanine-quadruplexes (G4s) in genomic DNA and RNA inhibits replication, transcription, and translation. Although several regions of the human genome exhibit G4-forming potential, the stability...
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Article
Open AccessMonitoring and kinetic analysis of the molecular interactions by which a repressor protein, PhaR, binds to target DNAs and poly[(R)-3-hydroxybutyrate]
The repressor protein PhaR, which is a component of poly[(R)-3-hydroxybutyrate] granules, functions as a repressor of the gene expression of the phasin PhaP and of PhaR itself. We used a quartz crystal microbalan...
