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  1. Article

    Open Access

    Neferine induces autophagy-dependent cell death in apoptosis-resistant cancers via ryanodine receptor and Ca2+-dependent mechanism

    Resistance of cancer cells to chemotherapy is a significant clinical concern and mechanisms regulating cell death in cancer therapy, including apoptosis, autophagy or necrosis, have been extensively investigat...

    Betty Yuen Kwan Law, Francesco Michelangeli, Yuan Qing Qu, Su-Wei Xu… in Scientific Reports (2019)

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  2. Article

    Open Access

    (Z)3,4,5,4′-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small cell lung cancer via selectively elevating intracellular calcium level

    Calcium is a second messenger which is required for regulation of many cellular processes. However, excessive elevation or prolonged activation of calcium signaling would lead to cell death. As such, selective...

    **ng-**ng Fan, **ao-Jun Yao, Su Wei Xu, Vincent Kam-Wai Wong… in Scientific Reports (2015)

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  3. Article

    Open Access

    Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells

    Resistance of cancer cells to chemotherapy is a significant problem in oncology and the development of sensitising agents or small-molecules with new mechanisms of action to kill these cells is needed. Autopha...

    Betty Yuen Kwan Law, Wai Kit Chan, Su Wei Xu, **g Rong Wang… in Scientific Reports (2014)

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