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Article
Open AccessL-DOPA regulates neuroinflammation and Aβ pathology through NEP and ADAM17 in a mouse model of AD
Dopamine plays important roles in cognitive function and inflammation and therefore is involved in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). Drugs that increase or mai...
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Article
Open AccessA naturally occurring variant of SHLP2 is a protective factor in Parkinson’s disease
Mitochondrial DNA single nucleotide polymorphisms (mtSNPs) have been associated with a reduced risk of develo** Parkinson’s disease (PD), yet the underlying mechanisms remain elusive. In this study, we inves...
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Article
Open AccessCeramide synthase 4 overexpression exerts oncogenic properties in breast cancer
Ceramide, a bioactive signaling sphingolipid, has long been implicated in cancer. Members of the ceramide synthase (CerS) family determine the acyl chain lengths of ceramides, with ceramide synthase 4 (CerS4) ...
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Article
Correction: Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE
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Article
Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE
Mitochondrial DNA variants have previously associated with disease, but the underlying mechanisms have been largely elusive. Here, we report that mitochondrial SNP rs2853499 associated with Alzheimer’s disease...
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Article
Open AccessDevelopment of an implantable collamer lens sizing model: a retrospective study using ANTERION swept-source optical coherence tomography and a literature review
Optimal sizing for phakic intraocular lens (EVO-ICL with KS-AquaPort) implantation plays an important role in preventing postoperative complications. We aimed to formulate optimal lens sizing using ocular biom...
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Article
Changes in phenylalanine and glucosinolate concentrations in the leaves of kimchi cabbage colonized by Heteroconium chaetospira
Kimchi cabbage is the main ingredient in kimchi, and improvements in yield and quality are therefore meaningful for the health of the consumer and the kimchi industry. In light of this, the present study inves...
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Article
Global socioeconomic networks of the apparel industry: the case of the Los Angeles Fashion District
This study aims to identify the Fashion District as the point where the expansion of the global network meets a local context and to investigate the influence of the apparel industry’s global network on the sp...
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Article
Open AccessEffect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors
MOTS-c is a mitochondrial derived peptide with exercise mimetic activity that elicits beneficial effects on metabolism and exercise capacity. Furthermore, MOTS-c effects in humans are affected by race, potenti...
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Article
Mitochondrial-derived peptides in aging and age-related diseases
A decline in mitochondrial quality and activity has been associated with normal aging and correlated with the development of a wide range of age-related diseases. Here, we review the evidence that a decline in...
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Article
Open AccessHost mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples
SARS-CoV-2 induces a muted innate immune response compared to other respiratory viruses. Mitochondrial dynamics might partially mediate this effect of SARS-CoV-2 on innate immunity. Polypeptides encoded by ope...
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Article
Development of evaluation methods and determination of hardness variation with leaf order and tissue type of Kimchi cabbage during summer harvest
The texture of Kimchi cabbage was investigated by determining the hardness variation of midribs by leaf order and midrib position and analyzing the hardness characteristic by probe type. The objective of this ...
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Article
PCR Screening of Enterococcus faecalis from Mixture of Lactic Acid Bacteria Using Bile Salt Hydrolase Gene as a Selective Marker
It is very important to rapidly detect the contamination of Enterococcus faecalis in fermented foods such as Korean Kimchi to maintain its freshness since Kimchi is exported to all over the world. However, gene s...
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Article
Effects of Chitting Duration on Early Maturation of Potatoes in a Short Season Environment
The objective of this study was to assess the efficacy of pre-plant light-sprouting (chitting) on hastening the maturation of potato. Four cultivars with different maturities (‘Superior’, ‘Haryeong’, ‘Seohong’...
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Article
Synthesis of gold nanoparticles supported at graphene derivatives using green reductants and evaluation of their catalytic activity in 4-nitrophenol reduction
In this study, gold nanoparticles were supported at graphene derivatives (AuNPs@GDs) from chloroauric acid and graphene oxide (GO) by using sodium citrate, L-ascorbic acid, and 4-(2-hydroxyethyl)-1-piperazinee...
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Article
Open AccessDietary fat intake and age modulate the composition of the gut microbiota and colonic inflammation in C57BL/6J mice
More than half of the adult population worldwide is overweight or obese, while excess adiposity has been linked to chronic low-grade inflammation, contributing to the development of chronic diseases. Recent st...
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Article
Open AccessMetabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment
The mitochondrial-derived peptides (MDPs) are a novel group of natural occurring peptides that have important signaling functions and biological activity. Both humanin and small-humanin-like peptide 2 (SHLP2) ...
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Article
Open AccessGRSF1 is an age-related regulator of senescence
Senescent cells that accumulate in multiple tissues with age are thought to increase pathological phenotypes. The removal of senescent cells can improve lifespan and/or healthspan in mouse models. Global hypom...
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Article
MOTS-c: an equal opportunity insulin sensitizer
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Article
Open AccessHumanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans
Advanced age is associated with a decline in cognitive function, likely caused by a combination of modifiable and non-modifiable factors such as genetics and lifestyle choices. Mounting evidence suggests that ...
