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  1. Article

    Open Access

    Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2

    Cognitive dysfunction (CD) in heart failure (HF) adversely affects treatment compliance and quality of life. Although ryanodine receptor type 2 (RyR2) has been linked to cardiac muscle dysfunction, its role in...

    Haikel Dridi, Yang Liu, Steven Reiken, ** Liu… in Nature Neuroscience (2023)

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  2. No Access

    Article

    Defective cerebellar ryanodine receptor type 1 and endoplasmic reticulum calcium ‘leak’ in tremor pathophysiology

    Essential Tremor (ET) is a prevalent neurological disease characterized by an 8–10 Hz action tremor. Molecular mechanisms of ET remain poorly understood. Clinical data suggest the importance of the cerebellum ...

    Regina T. Martuscello, Meng-Ling Chen, Steven Reiken… in Acta Neuropathologica (2023)

  3. Article

    Open Access

    RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation

    The type 1 ryanodine receptor (RyR1) is an intracellular calcium (Ca2+) release channel on the sarcoplasmic/endoplasmic reticulum that is required for skeletal muscle contraction. RyR1 channel activity is modulat...

    Qi Yuan, Haikel Dridi, Oliver B. Clarke… in Acta Neuropathologica Communications (2021)

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  4. No Access

    Article

    Intracellular calcium leak as a therapeutic target for RYR1-related myopathies

    RYR1 encodes the type 1 ryanodine receptor, an intracellular calcium release channel (RyR1) on the skeletal muscle sarcoplasmic reticulum (SR). Pathogenic RYR1 variations can destabilize RyR1 leading to calcium l...

    Alexander Kushnir, Joshua J. Todd, Jessica W. Witherspoon, Qi Yuan… in Acta Neuropathologica (2020)

  5. No Access

    Article

    Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer’s disease-like pathologies and cognitive deficits

    The mechanisms underlying ryanodine receptor (RyR) dysfunction associated with Alzheimer disease (AD) are still not well understood. Here, we show that neuronal RyR2 channels undergo post-translational remodel...

    Alain Lacampagne, ** Liu, Steven Reiken, Renaud Bussiere… in Acta Neuropathologica (2017)

  6. No Access

    Article

    Excess TGF-β mediates muscle weakness associated with bone metastases in mice

    Metastasis-mediated osteolysis results in excess release of TGF-β that, in turn, leads to muscle weakness.

    David L Waning, Khalid S Mohammad, Steven Reiken, Wenjun **e… in Nature Medicine (2015)

  7. No Access

    Article

    Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

    Increased calcium levels in dystrophic muscle have damaging consequences. In this report, Bellinger et al. show that nitrosylation of the ryanodine receptor calcium channel, leading to calcium leak through the ch...

    Andrew M Bellinger, Steven Reiken, Christian Carlson, Marco Mongillo… in Nature Medicine (2009)