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Article
Open AccessPost-intensive care syndrome and health-related quality of life in long-term survivors of cardiac arrest: a prospective cohort study
Patients discharged from intensive care are at risk for post-intensive care syndrome (PICS), which consists of physical, psychological, and/or neurological impairments. This study aimed to analyze PICS at 24 m...
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Article
Open AccessEfficacy and Tolerability of Intranasal Midazolam Administration for Antiseizure Treatment in Adults: A Systematic Review
The objective of this study was to assess the efficacy and tolerability of intranasal midazolam (in-MDZ) administration for antiseizure treatment in adults.
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Article
Open AccessConcurrence of seizures and peri-ictal delirium in the critically ill - its frequency, associated characteristics, and outcomes
To assess the frequency, clinical features, and outcome of peri-ictal delirium in adult patients experiencing seizures during intensive care.
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Article
Open AccessDevelopment and validation of the Workplace Learning Inventory in Health Sciences Education: a multimethod study
Health sciences students face many challenges in regard to clinical practical learning. A better understanding of student learning is required to address student needs in this crucial phase. The theory of self...
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Article
Open AccessRed blood cell distribution width for the prediction of outcomes after cardiac arrest
The red blood cell distribution width (RDW) is a routinely available blood marker that measures the variation of the size/volume of red blood cells. The aim of our study was to investigate the prognostic valu...
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Article
Open AccessSex-related differences in adult patients with status epilepticus: a seven-year two-center observation
Conflicting findings exist regarding the influence of sex on the development, treatment, course, and outcome of status epilepticus (SE). Our study aimed to investigate sex-related disparities in adult SE patie...
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Article
Open AccessExternal validation of the PROLOGUE score to predict neurological outcome in adult patients after cardiac arrest: a prospective cohort study
The PROLOGUE score (PROgnostication using LOGistic regression model for Unselected adult cardiac arrest patients in the Early stages) is a novel prognostic model for the prediction of neurological outcome afte...
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Article
Open AccessPredicting neurological outcome in adult patients with cardiac arrest: systematic review and meta-analysis of prediction model performance
This work aims to assess the performance of two post-arrest (out-of-hospital cardiac arrest, OHCA, and cardiac arrest hospital prognosis, CAHP) and one pre-arrest (good outcome following attempted resuscitatio...
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Article
Open AccessComparison of different clinical risk scores to predict long-term survival and neurological outcome in adults after cardiac arrest: results from a prospective cohort study
Several scoring systems have been used to predict short-term outcome in patients with out-of-hospital cardiac arrest (OHCA), including the disease-specific OHCA and CAHP (Cardiac Arrest Hospital Prognosis) sco...
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Article
Open AccessSeizures and risks for recurrence in critically ill patients: an observational cohort study
To assess the frequency and clinical characteristics of seizures in adult critically ill patients, to identify predictors of recurrent seizures not transforming into status epilepticus and to characterize thei...
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Article
Open AccessSimulation-based randomized trial of medical emergency cognitive aids
Medical emergencies are complex and stressful, especially for the young and inexperienced. Cognitive aids (CA) have been shown to facilitate management of simulated medical emergencies by experienced teams. In...
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Article
Open AccessA beginner’s view of end of life care on German intensive care units
Little is known about importance and implementation of end-of-life care (EOLC) in German intensive care units (ICU). This survey analyses preferences and differences in training between “medical” (internal med...
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Article
Open AccessDiagnostic yield of cerebrospinal fluid analysis in status epilepticus: an 8-year cohort study
We investigate the frequency and diagnostic yield of cerebrospinal fluid (CSF) analysis in adult patients with status epilepticus (SE) and its impact on the outcome.
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Article
Open AccessSerum neurofilament measurement improves clinical risk scores for outcome prediction after cardiac arrest: results of a prospective study
A recent study found serum neurofilament light chain (NfL) levels to be strongly associated with poor neurological outcome in patients after cardiac arrest. Our aim was to confirm these findings in an independ...
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Article
Open AccessCommunity-acquired and hospital-acquired respiratory tract infection and bloodstream infection in patients hospitalized with COVID-19 pneumonia
SARS-CoV-2 may cause acute lung injury, and secondary infections are thus relevant complications in patients with COVID-19 pneumonia. However, detailed information on community- and hospital-acquired infection...
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Article
Open AccessPredictors of infectious meningitis or encephalitis: the yield of cerebrospinal fluid in a cross-sectional study
Cerebrospinal fluid (CSF) analyses are recommended in patients with meningitis and/or encephalitis, but evidence regarding its diagnostic yield is low. We aimed to determine predictors of infectious pathogens ...
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Article
Anesthetics and Outcome in Status Epilepticus: A Matched Two-Center Cohort Study
The use of anesthetics has been linked to poor outcome in patients with status epilepticus (SE). This association, however, may be confounded, as anesthetics are mostly administered in patients with more sever...
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Article
Open AccessRisk factors for new-onset delirium in patients with bloodstream infections: independent and quantitative effect of catheters and drainages—a four-year cohort study
Bloodstream infections (BSI) and delirium are frequent in critically ill patients. During systemic inflammatory response to BSI, cytokines may interact with neurotransmitters and neuronal receptors driving acu...
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Article
Independent impact of infections on the course and outcome of status epilepticus: a 10-year cohort study
Infections are frequent in patients with status epilepticus (SE). It remains unclear if infections merely reflect severity of the underlying illness or if they independently predict unfavourable course and out...
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Article
Open AccessProcalcitonin and mortality in status epilepticus: an observational cohort study
Acute-phase proteins, such as procalcitonin (PCT), C-reactive protein (CRP) and albumin, may relate with course and outcome in status epilepticus (SE), as seizures bring about inflammation, changes of cytokine...
