35 Result(s)
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Stanley A. Schwartz
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Article
Correction to: Mitochondrial Dynamics in SARS‑COV2 Spike Protein Treated Human Microglia: Implications for Neuro‑COVID
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Article
Mitochondrial Dynamics in SARS-COV2 Spike Protein Treated Human Microglia: Implications for Neuro-COVID
Emerging clinical data from the current COVID-19 pandemic suggests that ~ 40% of COVID-19 patients develop neurological symptoms attributed to viral encephalitis while in COVID long haulers chronic neuro-infla...
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Article
Correction to: Targeted Anti-IL-5 Therapies and Future Therapeutics for Hypereosinophilic Syndrome and Rare Eosinophilic Conditions
The original version of this article unfortunately contained a mistake in the fifth paragraph of the “Conclusion” section.
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Article
Targeted Anti-IL-5 Therapies and Future Therapeutics for Hypereosinophilic Syndrome and Rare Eosinophilic Conditions
Eosinophilic inflammation is a component of many atopic diseases such as asthma, and biologics targeting eosinophils have been shown to be effective in subsets of these patients. However, there also are condit...
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Article
Effect of Dolutegravir and Sertraline on the Blood Brain Barrier (BBB)
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United States National Trends in Mortality, Length of Stay (LOS) and Associated Costs of Cognitive Impairment in HIV Population from 2005 to 2014
We evaluated national trends of in-hospital discharge rates, mortality outcomes, health care costs, length of stay in HIV patients with cognitive disorders. Neurological involvement in HIV is commonly associat...
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Article
Methamphetamine Induces Apoptosis of Microglia via the Intrinsic Mitochondrial-Dependent Pathway
Methamphetamine (METH) is a drug of abuse, the acute and chronic use of which induces neurotoxic responses in the human brain, ultimately leading to neurocognitive disorders. Our goals were to understand the i...
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Infections in Patients with Autoimmune Diseases
The relationship between autoimmunity and infections is complex and bi-directional. Infections have been associated with the induction of autoimmunity as well as protection from autoimmune diseases. Infectious...
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Galectin-1 Reduces Neuroinflammation via Modulation of Nitric Oxide-Arginase Signaling in HIV-1 Transfected Microglia: a Gold Nanoparticle-Galectin-1 “Nanoplex” a Possible Neurotherapeutic?
Galectins are a family of β-galactoside-binding lectins that are important modulators of homeostasis in the central nervous system (CNS). Galectin-1 is a pivotal regulator of microglia activation that alters t...
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Article
Single nucleotide polymorphisms (SNPs) in key cytokines may modulate food allergy phenotypes
Single nucleotide polymorphisms (SNPs) can play a direct or indirect role in phenotypic expression in food allergy pathogenesis. Our goal was to quantitate the expression of SNPs in relevant cytokines that wer...
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Article
Nanoparticle Based Galectin-1 Gene Silencing, Implications in Methamphetamine Regulation of HIV-1 Infection in Monocyte Derived Macrophages
Galectin-1, an adhesion molecule, is expressed in macrophages and implicated in human immunodeficiency virus (HIV-1) viral adsorption. In this study, we investigated the effects of methamphetamine on galectin-...
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Article
Modulation of the Proteome of Peripheral Blood Mononuclear Cells from HIV-1-Infected Patients by Drugs of Abuse
We used proteomic analyses to assess how drug abuse modulates immunologic responses to infections with the human immunodeficiency virus type 1 (HIV-1).
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Article
Tight Junction Regulation by Morphine and HIV-1 Tat Modulates Blood–Brain Barrier Permeability
Human immunodeficiency virus (HIV)-1 patients who abuse opiates are at a greater risk of develo** neurological complications of AIDS. Alterations in blood–brain barrier (BBB) integrity are associated with cy...
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Chapter
RNAi-Directed Inhibition of DC-SIGN by Dendritic Cells: Prospects for HIV-1 Therapy
Drag-resistant human immunodeficiency virus (HIV) infections are increasing globally, especially in North America. Therefore, it is logical to develop new therapies directed against HIV binding molecules on su...
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Article
Open AccessHuman Immunodeficiency Virus-Type 1 LTR DNA contains an intrinsic gene producing antisense RNA and protein products
While viruses have long been shown to capitalize on their limited genomic size by utilizing both strands of DNA or complementary DNA/RNA intermediates to code for viral proteins, it has been assumed that human...
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Article
Methamphetamine Modulates Gene Expression Patterns in Monocyte Derived Mature Dendritic Cells
Background: The US is currently experiencing a grave epidemic of methamphetamine use as a recreational drug, and the risk for HIV-1 infection attributable to methamphetamine use continues to incr...
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Article
RNAi-directed inhibition of DC-SIGN by dendritic cells: Prospects for HIV-1 therapy
Drug-resistant human immunodeficiency virus (HIV) infections are increasing globally, especially in North America. Therefore, it is logical to develop new therapies directed against HIV binding molecules on su...
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Article
Effector cell mediated cytotoxicity measured by intracellular Granzyme B release in HIV infected subjects
CD8+ cytotoxic T lymphocyte (CTL) activity is currently believed to be one of the key immunologic mechanisms responsible for the prevention or attenuation of HIV-1 infection. The induction of CD8+ T cell activ...
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Article
Immunological assays for chemokine detection in in-vitro culture of CNS cells
Herein we review the various methods currently in use for determining the expression of chemokines by CNS cells in vitro. Chemokine detection assays are used in conjuction with one another to provide a compreh...
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Chapter
Effect of Cocaine on Chemokine and CCR- 5 Gene Expression by Mononuclear Cells from Normal Donors and HIV-1 Infected Patients
