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Open AccessAuthor Correction: Federated learning enables big data for rare cancer boundary detection
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Open AccessFederated learning enables big data for rare cancer boundary detection
Although machine learning (ML) has shown promise across disciplines, out-of-sample generalizability is concerning. This is currently addressed by sharing multi-site data, but such centralization is challenging...
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Open AccessEWSR1-BEND2 fusion defines an epigenetically distinct subtype of astroblastoma
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Open AccessAuthor Correction: Topographic correlates of driver mutations and endogenous gene expression in pediatric diffuse midline gliomas and hemispheric high-grade gliomas
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Identification of magnetic resonance imaging features for the prediction of molecular profiles of newly diagnosed glioblastoma
We predicted molecular profiles in newly diagnosed glioblastoma patients using magnetic resonance (MR) imaging features and explored the associations between imaging features and major molecular alterations.
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Open AccessTopographic correlates of driver mutations and endogenous gene expression in pediatric diffuse midline gliomas and hemispheric high-grade gliomas
We evaluate the topographic distribution of diffuse midline gliomas and hemispheric high-grade gliomas in children with respect to their normal gene expression patterns and pathologic driver mutation patterns....
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Open AccessA fully automated artificial intelligence method for non-invasive, imaging-based identification of genetic alterations in glioblastomas
Glioblastoma is the most common malignant brain parenchymal tumor yet remains challenging to treat. The current standard of care—resection and chemoradiation—is limited in part due to the genetic heterogeneity...
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Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas
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Location of subventricular zone recurrence and its radiation dose predicts survival in patients with glioblastoma
Glioblastomas are aggressive brain tumors that frequently recur in the subventricular zone (SVZ) despite maximal treatment. The purpose of this study was to evaluate imaging patterns of subventricular progress...
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Early tumor growth between initial resection and radiotherapy of glioblastoma: incidence and impact on clinical outcomes
Early tumor growth, or increased contrast-enhancing tumor not related to evolving post-surgical injury, in the interval between surgical resection and initiation of radiotherapy has implications for treatment ...
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Quantitative multi-modal MR imaging as a non-invasive prognostic tool for patients with recurrent low-grade glioma
Low-grade gliomas can vary widely in disease course and therefore patient outcome. While current characterization relies on both histological and molecular analysis of tissue resected during surgery, there rem...
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Open AccessSerial analysis of 3D H-1 MRSI for patients with newly diagnosed GBM treated with combination therapy that includes bevacizumab
Interpretation of changes in the T1- and T2-weighted MR images from patients with newly diagnosed glioblastoma (GBM) treated with standard of care in conjunction with anti-angiogenic agents is complicated by p...
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Open AccessAdult-onset central nervous system hemophagocytic lymphohistiocytosis: a case report
Hemophagocytic lymphohistiocytosis (HLH) is a clinical syndrome with both genetic and acquired causes characterized by elevated cytokine levels, hyperinflammation, and overactivation of lymphocytes and macroph...
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Apparent diffusion coefficient in glioblastoma with PNET-like components, a GBM variant
Glioblastoma (GBM) with primitive neuroectodermal tumor (PNET)-like (GBM-PNET) components is a rare variant of GBM. Recent studies describe PNET-like clinical behavior in these patients—with significantly incr...
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Reference Work Entry In depth
Brain Cancer: Evidence-Based Neuroimaging
The term brain cancer, more commonly referred to as brain tumor, is used here to describe all primary and secondary neoplasms of the brain and its covering, including the leptomeninges, dura, skull, and scalp....
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Article
Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: a multi-center study
We have tested the predictive value of apparent diffusion coefficient (ADC) histogram analysis in stratifying progression-free survival (PFS) and overall survival (OS) in bevacizumab-treated patients with rec...
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Article
Ferumoxytol-Enhanced MRI to Image Inflammation Within Human Brain Arteriovenous Malformations: a Pilot Investigation
Inflammation cell infiltration and cytokine expression are seen in the vascular walls and intervening stroma of resected brain arteriovenous malformation (bAVM) specimens, even in unruptured and previously unt...
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Chapter
8 Imaging of Brain Cancer
Brain imaging is necessary for optimal localization, characterization, and management of brain cancer prior to surgery in patients with suspected or confirmed brain tumors (strong evidence). Due to its superio...
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Chapter
Modern Neuroimaging of Pediatric Brain Tumors
Neuroimaging has been an important tool in the diagnosis and surveillance of brain tumors for more than 30 years. Although magnetic resonance (MR) imaging remains the most important imaging tool for assessing ...
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Chapter
Imaging of Brain Neoplasm
■ Brain imaging is necessary for optimal localization, characterization, and management of pediatric brain cancer prior to surgery in patients with suspected or confirmed brain tumors (strong evidence).
