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Article
Dragonfly larvae as biosentinels of Hg bioaccumulation in Northeastern and Adirondack lakes: relationships to abiotic factors
Mercury (Hg) is a toxic pollutant, widespread in northeastern US ecosystems. Resource managers’ efforts to develop fish consumption advisories for humans and to focus conservation efforts for fish-eating wildl...
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Article
Contrasting stream nitrate and sulfate response to recovery from experimental watershed acidification
Improvements in air quality have led to ecosystem recovery from acidic deposition, but the mechanisms and trajectories of this recovery are not fully understood. Here, we present long-term stream response and ...
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Article
Snowmelt periods as hot moments for soil N dynamics: a case study in Maine, USA
The vernal transition represents the seasonal transition to spring, occurring as temperatures rise at the end of winter. With rapid snowmelt, microbial community turnover, and accelerated nutrient cycling, thi...
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Article
Correlation of Tumor Perfusion Between Carbon-13 Imaging with Hyperpolarized Pyruvate and Dynamic Susceptibility Contrast MRI in Pre-Clinical Model of Glioblastoma
The purpose of this study was to compare C-13 imaging parameters with hyperpolarized [1-13C]pyruvate with conventional gadolinium (Gd)-based perfusion weighted imaging using an orthotopic xenograft model of human...
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Article
Soil Nitrogen and Mercury Dynamics Seven Decades After a Fire Disturbance: a Case Study at Acadia National Park
Forest soils (mainly soil organic carbon) play an important role in the retention of nitrogen and mercury, and loss of the forest floor during wildfires can stimulate N and Hg losses. In this paper, we investi...
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Article
Open AccessFifteen–year record of soil temperature at the Bear Brook Watershed in Maine
This paper describes a record of air and soil temperature collected from 2001 to 2016 in temperate forests at the Bear Brook Watershed in Maine (BBWM). BBWM is a long-term research site established to study th...
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Article
Open AccessMetabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma
Infiltrating low grade gliomas (LGGs) are heterogeneous in their behavior and the strategies used for clinical management are highly variable. A key factor in clinical decision-making is that patients with mut...
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Article
Quantitative multi-modal MR imaging as a non-invasive prognostic tool for patients with recurrent low-grade glioma
Low-grade gliomas can vary widely in disease course and therefore patient outcome. While current characterization relies on both histological and molecular analysis of tissue resected during surgery, there rem...
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Article
Paleolimnological evidence of the consequences of recent increased dissolved organic carbon (DOC) in lakes of the northeastern USA
As a result of reductions in sulfate deposition and changing climate, dissolved organic carbon (DOC) concentrations have increased in many lakes situated in forests of northeastern North America and northern E...
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Article
Regional meteorological drivers and long term trends of winter-spring nitrate dynamics across watersheds in northeastern North America
This study evaluated the contribution of winter rain-on-snow (ROS) events to annual and seasonal nitrate (N-NO3) export and identified the regional meteorological drivers of inter-annual variability in ROS N-NO3
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Article
Open AccessSerial analysis of 3D H-1 MRSI for patients with newly diagnosed GBM treated with combination therapy that includes bevacizumab
Interpretation of changes in the T1- and T2-weighted MR images from patients with newly diagnosed glioblastoma (GBM) treated with standard of care in conjunction with anti-angiogenic agents is complicated by p...
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Article
Ultrashort echo time and zero echo time MRI at 7T
Zero echo time (ZTE) and ultrashort echo time (UTE) pulse sequences for MRI offer unique advantages of being able to detect signal from rapidly decaying short-T2 tissue components. In this paper, we applied 3D...
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Article
Open AccessEvaluating metabolites in patients with major depressive disorder who received mindfulness-based cognitive therapy and healthy controls using short echo MRSI at 7 Tesla
Our aim was to evaluate differences in metabolite levels between unmedicated patients with major depressive disorder (MDD) and healthy controls, to assess changes in metabolites in patients after they complete...
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Article
Extreme weather years drive episodic changes in lake chemistry: implications for recovery from sulfate deposition and long-term trends in dissolved organic carbon
Interannual climate variability is expected to increase over the next century, but the extent to which hydroclimatic variability influences biogeochemical processes is unclear. To determine the effects of extr...
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Article
Open AccessComparison of ADC metrics and their association with outcome for patients with newly diagnosed glioblastoma being treated with radiation therapy, temozolomide, erlotinib and bevacizumab
To evaluate metrics that describe changes in apparent diffusion coefficient (ADC) and to examine their association with clinical outcome for patients with newly diagnosed GBM who were participating in a Phase ...
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Article
Susceptibility-weighted MR imaging of radiation therapy-induced cerebral microbleeds in patients with glioma: a comparison between 3T and 7T
Cerebral microbleeds have been observed in normal-appearing brain tissue of patients with glioma years after receiving radiation therapy. The contrast of these paramagnetic lesions varies with field strength d...
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Article
Shifts in controls on the temporal coherence of throughfall chemical flux in Acadia National Park, Maine, USA
Major ion and mercury (Hg) inputs to terrestrial ecosystems include both wet and dry deposition (total deposition). Estimating total deposition to sensitive receptor sites is hampered by limited information re...
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Article
Non-invasive in vivo assessment of IDH1 mutational status in glioma
Gain-of-function mutations of the isocitrate dehydrogenase 1 (IDH1) gene are among the most prevalent in low-grade gliomas and secondary glioblastoma. They lead to intracellular accumulation of the oncometabolite...
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Article
Open AccessImplementation of 3 T Lactate-Edited 3D 1H MR Spectroscopic Imaging with Flyback Echo-Planar Readout for Gliomas Patients
The purpose of this study was to implement a new lactate-edited 3D 1H magnetic resonance spectroscopic imaging (MRSI) sequence at 3 T and demonstrate the feasibility of using this sequence for measuring lactate i...
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Article
Twenty-year inter-annual trends and seasonal variations in precipitation and stream water chemistry at the Bear Brook Watershed in Maine, USA
Mean annual concentration of \({\textrm{SO}}_{4}^{2-}\) in wet-only deposition has decreased between 1988 and 2006 at the paired watershed study at Bear Brook Watershed in Maine,...
