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Article
Open AccessA novel function of cIAP1 as a mediator of CHIP-driven eIF4E regulation
eIF4E is an initiator protein in cap-dependent translation. Its overexpression is linked to tumorigenesis in various human cancers, suggesting that the levels of eIF4E must be under tight control in normal cel...
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Article
Chfr is linked to tumour metastasis through the downregulation of HDAC1
The ubiquitin ligase Chfr polyubiquitylates the histone deacetylase Hdac1, resulting in its proteolysis and the concomitant upregulation of metastasis suppressors, which may provide a molecular explanation for...
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Article
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
The PINK1 gene was recently implicated in autosomal recessive juvenile Parkinson's disease. Two groups have studied the equivalent gene in the fruitfly Drosophila, and find that it localizes to mitochondria in vi...
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Article
Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms
Inhibitor of apoptosis (IAP) proteins suppress apoptosis and inhibit caspases. Several IAPs also function as ubiquitin-protein ligases. Regulators of IAP auto-ubiquitination, and thus IAP levels, have yet to b...