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  1. Article

    Open Access

    A novel function of cIAP1 as a mediator of CHIP-driven eIF4E regulation

    eIF4E is an initiator protein in cap-dependent translation. Its overexpression is linked to tumorigenesis in various human cancers, suggesting that the levels of eIF4E must be under tight control in normal cel...

    Tae Woong Seo, Ji Sun Lee, Ye Na Choi, Dar Heum Jeong, Sun Kyung Lee… in Scientific Reports (2017)

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  2. No Access

    Article

    Chfr is linked to tumour metastasis through the downregulation of HDAC1

    The ubiquitin ligase Chfr polyubiquitylates the histone deacetylase Hdac1, resulting in its proteolysis and the concomitant upregulation of metastasis suppressors, which may provide a molecular explanation for...

    Young Mi Oh, Young Eun Kwon, Joo Mi Kim, Sung Jun Bae, Bo Keun Lee… in Nature Cell Biology (2009)

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    Article

    Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

    The PINK1 gene was recently implicated in autosomal recessive juvenile Parkinson's disease. Two groups have studied the equivalent gene in the fruitfly Drosophila, and find that it localizes to mitochondria in vi...

    Ira E. Clark, Mark W. Dodson, Changan Jiang, Joseph H. Cao, Jun R. Huh… in Nature (2006)

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    Article

    Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms

    Inhibitor of apoptosis (IAP) proteins suppress apoptosis and inhibit caspases. Several IAPs also function as ubiquitin-protein ligases. Regulators of IAP auto-ubiquitination, and thus IAP levels, have yet to b...

    Soon Ji Yoo, Jun R. Huh, Israel Muro, Hong Yu, Lijuan Wang… in Nature Cell Biology (2002)