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  1. No Access

    Article

    Analysis of neurotransmitter release mechanisms by photolysis of caged Ca2+ in an autaptic neuron culture system

    Neurotransmitter release is triggered by membrane depolarization, Ca2+ influx and Ca2+ sensing by the release machinery, causing synaptic vesicle (SV) fusion with the plasma membrane. Interlinked is a complex mem...

    Andrea Burgalossi, SangYong Jung, Kwun-nok Mimi Man, Ramya Nair… in Nature Protocols (2012)

  2. Article

    Open Access

    Expression of constitutively active erythropoietin receptor in pyramidal neurons of cortex and hippocampus boosts higher cognitive functions in mice

    Erythropoietin (EPO) and its receptor (EPOR) are expressed in the develo** brain and their transcription is upregulated in adult neurons and glia upon injury or neurodegeneration. We have shown neuroprotecti...

    Derya Sargin, Ahmed El-Kordi, Amit Agarwal, Michael Müller, Sonja M Wojcik… in BMC Biology (2011)

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  3. No Access

    Article

    Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

    Munc13 primes synaptic vesicles for exocytosis. Studies now reveal that the central C2B domain of Munc13 contains a structurally unusual Ca2+ binding site that confers specific phospholipid-binding properties to ...

    Ok-Ho Shin, Jun Lu, Jeong-Seop Rhee… in Nature Structural & Molecular Biology (2010)