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Article
Small intestinal CaSR-dependent and CaSR-independent protein sensing regulates feeding and glucose tolerance in rats
Proteins activate small intestinal calcium sensing receptor (CaSR) and/or peptide transporter 1 (PepT1) to increase hormone secretion1–8, but the effect of small intestinal protein sensing and the mechanistic pot...
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Article
Open AccessMetabolic regulation by the intestinal metformin-AMPK axis
AMP-activated protein kinase (AMPK) mediates the glucose-lowering effect of the antidiabetic agent metformin, but the sites of action remain unclear. In the March issue of Nature Communications, Zhang and coll...
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Article
Open AccessInhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production
Glucose homeostasis is partly controlled by the energy sensor mechanistic target of rapamycin (mTOR) in the muscle and liver. However, whether mTOR in the small intestine affects glucose homeostasis in vivo re...
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Article
Omega-3 PUFA ameliorates hyperhomocysteinemia-induced hepatic steatosis in mice by inhibiting hepatic ceramide synthesis
Hyperhomocysteinemia (HHcy) is a key risk factor in hepatic steatosis. In this study, we applied a metabolomic approach to investigate the changes in the metabolite profile due to HHcy-induced hepatic steatosi...
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Article
Numerical simulation of the dual laterolog for carbonate cave reservoirs and response characteristics
Cave carbonate formations are characterized by heterogeneity, which makes electrical log prediction difficult. It is currently important to know how to use the dual laterolog to accurately identify and quantit...
