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  1. No Access

    Chapter

    Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes

    Engagement of T cell receptors (TCRs) with cognate antigens triggers cascades of signaling pathways in helper T cells. TCR signaling is essential for the effector function of helper T cells including prolifera...

    Sonal Srikanth, ** Seok Woo, Zuoming Sun… in Store-Operated Ca²⁺ Entry (SOCE) Pathways (2017)

  2. No Access

    Article

    Orai1-NFAT signalling pathway triggered by T cell receptor stimulation

    T cell receptor (TCR) stimulation plays a crucial role in development, homeostasis, proliferation, cell death, cytokine production, and differentiation of T cells. Thus, in depth understanding of TCR signallin...

    Sonal Srikanth, Yousang Gwack in Molecules and Cells (2013)

  3. No Access

    Article

    A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells

    The calcium-binding protein CRACR2A positively regulates the activity of CRAC channels. CRACR2A is a ternary complex which binds to, and stabilizes, the interaction between STIM1 and Orai1, and disassociates a...

    Sonal Srikanth, Hea-** Jung, Kyun-Do Kim, Puneet Souda… in Nature Cell Biology (2010)