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Article
IL4Rα and IL17A Blockade Rescue Autoinflammation in SOCS1 Haploinsufficiency
By inhibition of JAK-STAT signaling, SOCS1 acts as a master regulator of the cytokine response across numerous tissue types and cytokine pathways. Haploinsufficiency of SOCS1 has recently emerged as a monogeni...
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Article
Autoimmunity in Down’s syndrome via cytokines, CD4 T cells and CD11c+ B cells
Down’s syndrome (DS) presents with a constellation of cardiac, neurocognitive and growth impairments. Individuals with DS are also prone to severe infections and autoimmunity including thyroiditis, type 1 diab...
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Article
Open AccessAn ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants
The SARS-CoV-2 variants replacing the first wave strain pose an increased threat by their potential ability to escape pre-existing humoral protection. An angiotensin converting enzyme 2 (ACE2) decoy that compe...
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Article
Open AccessISG15 deficiency and increased viral resistance in humans but not mice
ISG15 is an interferon (IFN)-α/β-induced ubiquitin-like protein. It exists as a free molecule, intracellularly and extracellularly, and conjugated to target proteins. Studies in mice have demonstrated a role f...
