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Article
Recent Advances in 0D Ni/Co-based Hollow Electrocatalysts for Electrochemical Water Splitting
Electrochemical water splitting using renewable energy sources has been recognized as a sustainable way to produce hydrogen energy due to the characteristics of low-carbon and no pollution. However, the slow h...
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Article
Open AccessReconstitution of human PDAC using primary cells reveals oncogenic transcriptomic features at tumor onset
Animal studies have demonstrated the ability of pancreatic acinar cells to transform into pancreatic ductal adenocarcinoma (PDAC). However, the tumorigenic potential of human pancreatic acinar cells remains un...
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Article
Open AccessPhysiological and psychological responses to tended plant communities with varying color characteristics
Exposure to plants has been reported to promote health and reduce stress, and plant color has direct impacts on physical and mental health. We used images of common types of tended plant communities in Shenyan...
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Article
An Increase in Peroxiredoxin 6 Expression Induces Neurotoxic A1 Astrocytes in the Lumbar Spinal Cord of Amyotrophic Lateral Sclerosis Mice Model
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease with selective degeneration of motor neurons. It has been reported that an increase in the levels of inflammatory cytokines and glial c...
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Article
Open AccessGenomic profiling of subcutaneous patient-derived xenografts reveals immune constraints on tumor evolution in childhood solid cancer
Subcutaneous patient-derived xenografts (PDXs) are an important tool for childhood cancer research. Here, we describe a resource of 68 early passage PDXs established from 65 pediatric solid tumor patients. Thr...
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Article
Open AccessDepression severity mediates stigma and quality of life in clinically stable people with schizophrenia in rural China
Depressive symptoms associated with schizophrenia are closely related to stigma and quality of life(QOL). There is, however, no thorough research on the connection between the three. This study sought to inves...
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Article
Open AccessPHF5A regulates the expression of the DOCK5 variant to promote HNSCC progression through p38 MAPK activation
Previously, we identified an oncogenic splicing variant of DOCK5 in head and neck squamous cell carcinoma (HNSCC); however, the mechanism for the generation of this specific DOCK5 variant remains unknown. This...
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Article
Open AccessGenomic disparities between cancers in adolescent and young adults and in older adults
Cancers cause significant mortality and morbidity in adolescents and young adults (AYAs), but their biological underpinnings are incompletely understood. Here, we analyze clinical and genomic disparities betwe...
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Article
Effect of metformin and exenatide on pregnancy rate and pregnancy outcomes in overweight or obese infertility PCOS women: long-term follow-up of an RCT
The majority of Polycystic ovary syndrome (PCOS) are overweight or obese with increased infertility and high risk of pregnancy complications. We aim to compare efficacy of metformin and exenatide on spontaneou...
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Article
The study on characteristics of S wave coda Q in Chongqing area
In this paper, we select 93 seismic waveform recorded from 2009 to 2011 within 400 km of Chongqing and use the single scattering model to calculate the coda attenuation. Then, based on the multiple anisotropic...
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Article
Heterologous expression of Vitis vinifera SNF1-related kinase 1.1 gene in Arabidopsis akin10 mutant reveals sthe signaling regulatory network of sucrose metabolism
Grapevine (Vitis vinifera L.) is the widely cultivated important fruit crop. The regulation of sucrose metabolism is relevant for the quality improvement of grape berry. Despite the fact that SnRK1 has been sugge...
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Article
Open AccessIntegrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation
Active telomerase is essential for stem cells and most cancers to maintain telomeres. The enzymatic activity of telomerase is related but not equivalent to the expression of TERT, the catalytic subunit of the ...
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Article
Open AccessMurine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution
Recent characterization of spatiotemporal genomic architecture of IDH-wild-type multifocal glioblastomas (M-GBMs) suggests a clinically unobserved common-ancestor (CA) with a less aggressive phenotype, generating...
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Article
Prospective use of the single-mouse experimental design for the evaluation of PLX038A
Defining robust criteria for drug activity in preclinical studies allows for fewer animals per treatment group, and potentially allows for inclusion of additional cancer models that more accurately represent g...
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Article
Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma
To understand how genomic heterogeneity of glioblastoma (GBM) contributes to poor therapy response, we performed DNA and RNA sequencing on GBM samples and the neurospheres and orthotopic xenograft models deriv...
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Article
Open AccessBenchmarking: contexts and details matter
Benchmarking is an essential step in the development of computational tools. We take this opportunity to pitch in our opinions on tool benchmarking, in light of two correspondence articles published in Genome Bio...
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Article
Systematic analysis of telomere length and somatic alterations in 31 cancer types
Siyuan Zheng, Roel Verhaak and colleagues report an analysis of telomere lengths and somatic alterations in telomere-related pathways across 31 cancer types. Their study provides an overview of the molecular m...
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Article
Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation
Jian Hu and colleagues use mouse models to show that Qki deficiency promotes gliomagenesis by allowing neural stem cells to maintain their stemness outside the subventricular zone. Mechanistically, they show t...
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Article
Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain
Glioblastoma (GBM) is a devastating tumor and few patients survive beyond 3 years. Defining the molecular determinants underlying long-term survival is essential for insights into tumor biology and biomarker i...
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Article
The Pan-Cancer analysis of pseudogene expression reveals biologically and clinically relevant tumour subtypes
Although individual pseudogenes have been implicated in tumour biology, the biomedical significance and clinical relevance of pseudogene expression have not been assessed in a systematic way. Here we generate ...
