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Article
Open AccessLPA1 antagonist-derived LNPs deliver A20 mRNA and promote anti-fibrotic activities
Activated fibroblasts are major mediators of pulmonary fibrosis. Fibroblasts are generally found in the connective tissue but upon activation can generate excess extracellular matrix (ECM) in the lung intersti...
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Article
Open AccessIs it what you say or how you say it?
This study investigates the mechanisms driving the effectiveness of free-form communication in promoting cooperation within a sequential social dilemma game. We hypothesize that the self-constructing nature of...
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Article
Open AccessCD248-expressing cancer-associated fibroblasts induce epithelial–mesenchymal transition of non-small cell lung cancer via inducing M2-polarized macrophages
Non-small cell lung cancer (NSCLC)-originating cancer-associated fibroblasts (CAFs) expressing CD248 regulate interaction with immune cells to accelerate cancer progression. Epithelial–mesenchymal transition (...
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Article
Open AccessDNA methylation patterns in patients with asthenospermia and oligoasthenospermia
Spermatogenesis is a highly regulated and complex process in which DNA methylation plays a crucial role. This study aimed to explore the differential methylation profiles in sperm DNA between patients with ast...
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Article
Open AccessHBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription
Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in multiple biological processes. However, the regulatory mechanism and functional consequence of Kla remain to be explored. H...
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Article
Open AccessLNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing
Adipose stem cells (ASCs) have attracted considerable attention as potential therapeutic agents due to their ability to promote tissue regeneration. However, their limited tissue repair capability has posed a ...
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Article
Open AccessClinical efficacy of percutaneous endoscopic posterior lumbar interbody fusion and modified posterior lumbar interbody fusion in the treatment of lumbar degenerative disease
To compare the early clinical efficacy of percutaneous endoscopic posterior lumbar interbody fusion (PE-PLIF) and modified posterior lumbar interbody fusion (MPLIF) in the treatment of lumbar degenerative dise...
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Article
Open AccessIntra-ovarian inflammatory states and their associations with embryo quality in normal-BMI PCOS patients undergoing IVF treatment
Polycystic ovary syndrome (PCOS) is the main cause of anovulatory infertility in women of reproductive age, and low-grade chronic inflammation plays a key role in the occurrence and development of PCOS. Howeve...
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Article
Open AccessLower serum testosterone is associated with increased likelihood of arthritis
Studies have suggested that serum testosterone levels may be strongly correlated with the pathogenesis of arthritis. Therefore, the aim of this study was to assess the relationship between serum testosterone l...
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Article
Open AccessTyrosine phosphorylation of band 3 impairs the storage quality of suspended red blood cells in the Tibetan high-altitude polycythemia population
Due to environmental hypoxia on the Tibetan Plateau, local residents often exhibit a compensative increase in hemoglobin concentration to maintain the body’s oxygen supply. However, increases in hemoglobin and...
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Article
Open AccessIntrinsically motivated reinforcement learning based recommendation with counterfactual data augmentation
Deep reinforcement learning (DRL) has shown promising results in modeling dynamic user preferences in RS in recent literature. However, training a DRL agent in the sparse RS environment poses a significant cha...
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Article
Open AccessAssociation of mitochondrial DNA variation with high myopia in a Han Chinese population
High myopia (HM), which is characterized by oxidative stress, is one of the leading causes of visual impairment and blindness across the world. Family and population genetic studies have uncovered nuclear-geno...
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Article
Open AccessCorrelation between bone mineral density and sarcopenia in US adults: a population-based study
In the aging process of the body, in addition to changes in fat and muscle content, there is also bone loss, implying the possibility of a strong muscle–bone–lipid link. In this study, we initially investigate...
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Open AccessType 2 diabetes mellitus plays a protective role against osteoporosis --mendelian randomization analysis
Type 2 diabetes mellitus (DM2) and osteoporosis (OP) are currently the two most significant causes of mortality and morbidity in older adults, according to clinical evidence. The intrinsic link between them is...
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Article
Open AccessShort-term PET-derived kinetic estimation for the diagnosis of hepatocellular carcinoma: a combination of the maximum-slope method and dual-input three-compartment model
Kinetic estimation provides fitted parameters related to blood flow perfusion and fluorine-18-fluorodeoxyglucose (18F-FDG) transport and intracellular metabolism to characterize hepatocellular carcinoma (HCC) but...
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Open AccessCorrection: YOLO POD: a fast and accurate multi-task model for dense Soybean Pod counting
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Article
Open AccessHeterogeneous scene matching based on the gradient direction distribution field
Heterogeneous scene matching is a key technology in the field of computer vision. The image rotation problem is popular and difficult in the field of heterogeneous scene matching. In this paper, a heterogeneou...
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Article
Open AccessCryptococcus neoformans, a global threat to human health
Emerging fungal pathogens pose important threats to global public health. The World Health Organization has responded to the rising threat of traditionally neglected fungal infections by develo** a Fungal Pr...
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Article
Open AccessYOLO POD: a fast and accurate multi-task model for dense Soybean Pod counting
The number of soybean pods is one of the most important indicators of soybean yield, pod counting is crucial for yield estimation, cultivation management, and variety breeding. Counting pods manually is slow a...
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Article
Open AccessThe regulatory role and therapeutic application of pyroptosis in musculoskeletal diseases
Pyroptosis is a controlled form of inflammatory cell death characterized by inflammasome activation, pore formation, and cell lysis. According to different caspases, pyroptosis can be divided into canonical, n...
