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Protocol
Molecular Tension Probe for In Vitro Bioassays
Cell-free bioassays (CFBs) provide their own distinctive merits over cell-based bioassays (CBBs) including (i) rapid and on-site applicability, (ii) long-term utility, and (iii) bioanalytical versatility. The ...
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Article
Isoform-selective regulation of mammalian cryptochromes
CRY1 and CRY2 are essential components of the circadian clock controlling daily physiological rhythms. Accumulating evidences indicate distinct roles of these highly homologous proteins, in addition to redunda...
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Article
COMPASS II: extended coverage for polymer and drug-like molecule databases
The COMPASS II force field has been developed by extending the coverage of the COMPASS force field (J Phys Chem B 102(38):7338–7364, 1998) to polymer and drug-like molecules found in popular databases. Using a fr...
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Protocol
A Bioluminescence Assay System for Imaging Metal Cationic Activities in Urban Aerosols
A bioluminescence-based assay system was fabricated for an efficient determination of the activities of air pollutants. The following four components were integrated into this assay system: (1) an 8-channel as...
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Article
Cation-driven Optical Properties of Artificial Luciferases
The present study demonstrates cation-driven optical properties of artificial luciferases (ALucs) from copepod luciferases, as an optical readout for bioanalysis. An assignment of the supersecondary structure ...
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Chapter
Hotspots Analysis: Providing the Focus for Action
The technique ‘hotspots analysis’ belongs to the toolbox life cycle management. ‘Hotspotting’ or ‘hotspots analysis’ is an emergent technique being used in a growing number of different analytical disciplines,...
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Article
Dysphagia in Duchenne Muscular Dystrophy Assessed Objectively by Surface Electromyography
Objective swallowing assessment is indicated in the management of patients with Duchenne muscular dystrophy (DMD). Surface electromyography (sEMG) provides a non-invasive, objective method of quantifying muscl...
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Article
Interval type-2 fuzzy modelling and stochastic search for real-world inventory management
Real-world systems present a variety of challenges to the modeller, not least of which is the problem of uncertainty inherent in their operation. In this research, an interval type-2 fuzzy model is applied to ...
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Chapter and Conference Paper
Interval Type-2 Fuzzy Modelling and Simulated Annealing for Real-World Inventory Management
The modelling of real-world complex systems is an area of ongoing interest for the research community. Real-world systems present a variety of challenges not least of which is the problem of uncertainty inhere...
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Article
Correction: Corrigendum: The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors
Nat. Chem. Biol. 6, 117–124 (2010); published online 10 January 2010; corrected after print 12 February 2010 and 2 March 2010 In the version of this article initially published, the structure of p110δ in compl...
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Article
Correction: Corrigendum: The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors
Nat. Chem. Biol. 6, 117–124 (2010); published online 10 January 2010; corrected after print 12 February 2010 In the version of this article initially published, **da Ren was inadvertently left off the author...
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Article
The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors
Upregulation of PI(3)K signaling pathways is implicated in many diseases, and a number of inhibitors are currently in clinical development. The structure of a PI(3)Kδ kinase domain, along with co-complexes wit...
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Chapter and Conference Paper
An Interval Type-2 Fuzzy Multiple Echelon Supply Chain Model
Planning resources for a supply chain is a major factor determining its success or failure. In this paper we build on previous work introducing an Interval Type-2 Fuzzy Logic model of a multiple echelon supply ch...
