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Article
Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair
Osteoclasts are multinucleated cells of the monocyte/macrophage lineage that degrade bone. Here, we used lineage tracing studies—labelling cells expressing Cx3cr1, Csf1r or Flt3—to identify the precursors of oste...
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Article
Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis
Multiple sclerosis is a demyelinating neurodegenerative disease with a strong genetic component. Previous genetic risk studies have failed to identify consistently linked regions or genes outside of the major ...
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Article
Open AccessMap** and characterization of the amplicon near APOA2 in 1q23 in human sarcomas by FISH and array CGH
Amplification of the q21-q23 region on chromosome 1 is frequently found in sarcomas and a variety of other solid tumours. Previous analyses of sarcomas have indicated the presence of at least two separate ampl...
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Article
An SSLP marker–anchored BAC framework map of the mouse genome
We have constructed a BAC framework map of the mouse genome consisting of 2,808 PCR-confirmed BAC clusters, using a previously described method1. Fingerprints of BACs from selected clusters confirm the accuracy o...