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Article
Evaluation of a convolution neural network for baseline total tumor metabolic volume on [18F]FDG PET in diffuse large B cell lymphoma
New PET data-processing tools allow for automatic lesion selection and segmentation by a convolution neural network using artificial intelligence (AI) to obtain total metabolic tumor volume (TMTV) and total le...
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Article
Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis
Understanding the mechanisms underlying amyotrophic lateral sclerosis (ALS) is crucial for the development of new therapies. Previous studies have demonstrated that mitochondrial dysfunction is a key pathogene...
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Article
Author Correction: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease
A Correction to this paper has been published: https://doi.org/10.1038/s41591-021-01251-7.
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Article
Open AccessA multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer’s disease
Presenilin-1 (PSEN1) mutations cause familial Alzheimer’s disease (FAD) characterized by early age of onset (AoO). Examination of a large kindred harboring the PSEN1-E280A mutation reveals a range of AoO spann...
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Article
Open AccessSynaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds
Recent studies suggest that misfolded tau molecules can be released, and taken up by adjacent neurons, propagating proteopathic seeds across neural systems. Yet critical to understanding whether tau propagatio...
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Article
Open AccessTau reduction in aged mice does not impact Microangiopathy
Microangiopathy, including proliferation of small diameter capillaries, increasing vessel tortuosity, and increased capillary blockage by leukocytes, was previously observed in the aged rTg4510 mouse model. Si...
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Article
Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease
Alzheimer’s disease (AD) causes unrelenting, progressive cognitive impairments, but its course is heterogeneous, with a broad range of rates of cognitive decline1. The spread of tau aggregates (neurofibrillary ta...
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Article
Open AccessFrom the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy
The term “propagon” is used to define proteins that may transmit misfolding in vitro, in tissues or in organisms. Among propagons, misfolded tau is thought to be involved in the pathogenic mechanisms of variou...
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Article
Open AccessIn vivo detection of tau fibrils and amyloid β aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy
The detection of amyloid beta deposits and neurofibrillary tangles, both hallmarks of Alzheimer’s disease (AD), is key to understanding the mechanisms underlying these pathologies. Luminescent conjugated oligo...
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Article
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo
The coexistence of amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the neocortex is linked to neural system failure and cognitive decline in Alzheimer’s disease. However, the underlying neuronal mech...
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Tau Prion-Like Propagation: State of the Art and Current Challenges
It has been almost a decade since the hypothesis of active tau protein propagation in Alzheimer’s disease and associated tauopathies was formally raised. We view tau propagation as a cascade of events, startin...
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Article
Open AccessDifferent tau species lead to heterogeneous tau pathology propagation and misfolding
Tauopathies are a heterogeneous group of pathologies characterized by tau aggregation inside neurons. Most of them are sporadic but certain tauopathies rely on tau gene (MAPT) mutations. They particularly diff...
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Article
Open AccessWhat is the evidence that tau pathology spreads through prion-like propagation?
Emerging experimental evidence suggests that the spread of tau pathology in the brain in Tauopathies reflects the propagation of abnormal tau species along neuroanatomically connected brain areas. This propaga...
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Article
Open AccessTunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies
A given cell makes exchanges with its neighbors through a variety of means ranging from diffusible factors to vesicles. Cells use also tunneling nanotubes (TNTs), filamentous-actin-containing membranous struct...
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Article
Open AccessNeuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies
In sporadic Tauopathies, neurofibrillary degeneration (NFD) is characterised by the intraneuronal aggregation of wild-type Tau proteins. In the human brain, the hierarchical pathways of this neurodegeneration ...
