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Article
Open AccessSpecific detection of tau seeding activity in Alzheimer’s disease using rationally designed biosensor cells
The prion-like propagation of tau in neurodegenerative disorders implies that misfolded pathological tau can recruit the normal protein and template its aggregation. Here, we report the methods for the develop...
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Article
Open AccessTau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau
Insoluble fibrillar tau, the primary constituent of neurofibrillary tangles, has traditionally been thought to be the biologically active, toxic form of tau mediating neurodegeneration in Alzheimer’s disease. ...
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Article
Author Correction: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease
A Correction to this paper has been published: https://doi.org/10.1038/s41591-021-01251-7.
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Article
Open AccessSynaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds
Recent studies suggest that misfolded tau molecules can be released, and taken up by adjacent neurons, propagating proteopathic seeds across neural systems. Yet critical to understanding whether tau propagatio...
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Article
Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease
Alzheimer’s disease (AD) causes unrelenting, progressive cognitive impairments, but its course is heterogeneous, with a broad range of rates of cognitive decline1. The spread of tau aggregates (neurofibrillary ta...
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Article
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo
The coexistence of amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the neocortex is linked to neural system failure and cognitive decline in Alzheimer’s disease. However, the underlying neuronal mech...
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Article
Open AccessAn acute functional screen identifies an effective antibody targeting amyloid-β oligomers based on calcium imaging
Soluble amyloid β oligomers (AβOs) are widely recognized neurotoxins that trigger aberrant signaling in specific subsets of neurons, leading to accumulated neuronal damage and memory disorders in Alzheimer’s d...
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Article
Open AccessNeuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain
Tau pathology is known to spread in a hierarchical pattern in Alzheimer’s disease (AD) brain during disease progression, likely by trans-synaptic tau transfer between neurons. However, the tau species involved...
