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Article
Myosin Vb as a tumor suppressor gene in intestinal cancer
Colorectal cancer causes >900,000 deaths every year and a deeper understanding of the molecular mechanisms underlying this disease will contribute to improve its clinical management and survival. Myosin Vb (MYO5B
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Chapter
Drawbacks of Bench to Bed Translation of Nanomedicines for Cancer Treatment
Resistant metastatic cancer is at the moment an incurable disease and an unmet clinical need. It is one of the most lethal diseases and is causing thousands of deaths annually throughout the world. In this se...
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Article
Open AccessIdentification of ZBTB18 as a novel colorectal tumor suppressor gene through genome-wide promoter hypermethylation analysis
Cancer initiation and progression are driven by genetic and epigenetic changes. Although genome/exome sequencing has significantly contributed to the characterization of the genetic driver alterations, further...
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Article
Open AccessMechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer
Reduced RHOA signalling has been shown to increase the growth/metastatic potential of colorectal tumours. However, the mechanisms of inactivation of RHOA signalling in colon cancer have not been characterised.
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Chapter
Micellar-Based Nanoparticles for Cancer Therapy and Bioimaging
Micelles are versatile nanosized systems composed by amphiphilic molecules. Their small size and capacity to encapsulate both hydrophilic and hydrophobic compounds, as well as their easier functionalization, a...
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Article
Open AccessEffect of Specific Mutations in Cd300 Complexes Formation; Potential Implication of Cd300f in Multiple Sclerosis
Herein, we have used bioinformatics tools to predict five clusters defining ligand-binding sites on the extracellular domain of human CD300b receptor, presumably involved in the formation of both homodimers an...
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Article
Open AccessLoss of the EPH receptor B6 contributes to colorectal cancer metastasis
Although deregulation of EPHB signaling has been shown to be an important step in colorectal tumorigenesis, the role of EPHB6 in this process has not been investigated. We found here that manipulation of EPHB6...
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Article
Retraction Note: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
The authors have recently become aware of the presence of duplicated images in the Figures 3 and 4 and Supplementary Figures 5 and 6 in their publication, that were assembled according to the specified author ...
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Article
A novel bio-functional material based on mammalian cell aggresomes
Aggresomes are protein aggregates found in mammalian cells when the intracellular protein degradation machinery is over-titered. Despite that they abound in cells producing recombinant proteins of biomedical a...
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Article
Strategies for the production of difficult-to-express full-length eukaryotic proteins using microbial cell factories: production of human alpha-galactosidase A
Obtaining high levels of pure proteins remains the main bottleneck of many scientific and biotechnological studies. Among all the available recombinant expression systems, Escherichia coli facilitates gene expres...
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Article
RHOA inactivation enhances Wnt signalling and promotes colorectal cancer
Activation of the small GTPase RHOA has strong oncogenic effects in many tumour types, although its role in colorectal cancer remains unclear. Here we show that RHOA inactivation contributes to colorectal canc...
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Article
Open AccessSPARC mediates metastatic cooperation between CSC and non-CSC prostate cancer cell subpopulations
Tumor cell subpopulations can either compete with each other for nutrients and physical space within the tumor niche, or co-operate for enhanced survival, or replicative or metastatic capacities. Recently, we ...
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Article
Open AccessA new ex vivo method to evaluate the performance of candidate MRI contrast agents: a proof-of-concept study
Magnetic resonance imaging (MRI) plays an important role in tumor detection/diagnosis. The use of exogenous contrast agents (CAs) helps to improve the discrimination between lesion and neighbouring tissue, but...
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Article
Ex vivo assessment of polyol coated-iron oxide nanoparticles for MRI diagnosis applications: toxicological and MRI contrast enhancement effects
Polyol synthesis is a promising method to obtain directly pharmaceutical grade colloidal dispersion of superparamagnetic iron oxide nanoparticles (SPIONs). Here, we study the biocompatibility and performance a...
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Article
β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer
The crosstalk between the transcriptional activity of β-catenin and FOXO3a reveals unexpected pro-metastatic cooperative effects of these pathways through concurrent modulation of cell adhesion and motility pr...
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Article
Generation and characterization of orthotopic murine models for endometrial cancer
We describe the generation of two orthotopic murine models for endometrial cancer (EC).The first model is generated from endometrial Hec-1A cancer cells transfected with luciferase and injected directly into t...
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Article
Correction: Corrigendum: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
Nat. Genet. 41, 365–370 (2009); published online 15 February 2009; corrected after print 9 April 2010 In the version of this article initially published, the colony formation assay image labeled “Co115.DICER1”...
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Article
Effect of COX2 -765G>C and c.3618A>G polymorphisms on the risk and survival of sporadic colorectal cancer
The COX2 gene (also known as PTGS2) encodes one of the essential cyclooxygenases for the prostanoid synthesis, and its expression is tightly regulated at both transcriptional and posttranscriptional levels. COX2 ...
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Article
A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
Manel Esteller and colleagues report truncating mutations in TARBP2, an integral component of a DICER1-containing complex, in human colorectal cancers. This is the first report of a mutation in one of the genes i...
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Article
A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition
Disruption of histone acetylation patterns is a common feature of cancer cells, but very little is known about its genetic basis. We have identified truncating mutations in one of the primary human histone dea...
