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Article
Open AccessMidlife stress-related exhaustion and dementia incidence: a longitudinal study over 50 years in women
Cognitive problems are common symptoms among individuals with stress-related exhaustion. It is still unknown whether these individuals are at a higher risk of develo** dementia later. This study aims to exam...
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Article
Open AccessMass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies
Blood phosphorylated tau (p-tau) biomarkers, at differing sites, demonstrate high accuracy to detect Alzheimerʼs disease (AD). However, knowledge on the optimal marker for disease identification across the AD ...
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Article
Open AccessCerebrospinal fluid biomarkers of axonal and synaptic degeneration in a population-based sample
Neurofilament light (NfL) and neurogranin (Ng) are promising candidate AD biomarkers, reflecting axonal and synaptic damage, respectively. Since there is a need to understand the synaptic and axonal damage in ...
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Open AccessAuthor Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
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Article
Open AccessGenome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers
Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer’s disease (AD) more directly than clinical diagnosis. Initiated b...
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Article
Author Correction: A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease
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Article
Open AccessInteractions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds
To investigate potential interactions between dietary patterns and genetic factors modulating risk for Alzheimer’s disease (AD) in relation to incident dementia.
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The Capability Approach in Epidemiological Studies
Population epidemiology is the science that deals with disorders and certain conditions at the population level, i.e. at the macro-level. In contrast to experimental studies, the scientist in epidemiology cann...
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Article
Author Correction: A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease
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Article
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease
Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer’s disease have be...
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Article
Open AccessCommon variants in Alzheimer’s disease and risk stratification by polygenic risk scores
Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curat...
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Article
Open AccessDementia remains the major predictor of death among octogenarians. A study of two population cohorts of 85-year-olds examined 22 years apart
Dementia is the major predictor of death in old age. The aim of this paper was to determine whether 8-year mortality among 85-year olds with and without dementia, and if the contribution of dementia to mortali...
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Article
Open AccessAssociation of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds
Increased knowledge of the evolution of molecular changes in neurodegenerative disorders such as Alzheimer’s disease (AD) is important for the understanding of disease pathophysiology and also crucial to be ab...
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Article
Open AccessSoluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression
Soluble aggregates of amyloid-β (Aβ) have been associated with neuronal and synaptic loss in Alzheimer’s disease (AD). However, despite significant recent progress, the mechanisms by which these aggregated spe...
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Article
Open AccessAssociation of IL1RAP-related genetic variation with cerebrospinal fluid concentration of Alzheimer-associated tau protein
A possible involvement of the gene IL1RAP (interleukin-1 receptor-associated protein) in the pathogenesis of Alzheimer’s disease (AD) has been suggested in GWASs of cerebrospinal fluid (CSF) tau levels and longit...
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Article
Open AccessThe Gothenburg H70 Birth cohort study 2014–16: design, methods and study population
To improve health care for older persons, we need to learn more about ageing, e.g. identify protective factors and early markers for diseases. The Gothenburg H70 Birth Cohort Studies (the H70 studies) are mult...
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Article
Open AccessTrends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium
Several studies have reported a decline in incidence of dementia which may have large implications for the projected burden of disease, and provide important guidance to preventive efforts. However, reports ar...
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Open AccessDecreasing prevalence of dementia in 85-year olds examined 22 years apart: the influence of education and stroke
Individuals aged 80 years and older constitute the fastest growing segment of the population worldwide, leading to an expected increase in dementia cases. Education level and treatment of vascular risk factors...
