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Open AccessMidlife stress-related exhaustion and dementia incidence: a longitudinal study over 50 years in women
Cognitive problems are common symptoms among individuals with stress-related exhaustion. It is still unknown whether these individuals are at a higher risk of develo** dementia later. This study aims to exam...
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Article
Open AccessEffects of current alcohol use on brain volume among older adults in the Gothenburg H70 Birth Cohort study 2014–16
Brain gray- and white matter changes is well described in alcohol-dependent elderly subjects; however, the effect of lower levels of alcohol consumption on the brain is poorly understood. We investigated the i...
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Article
Open AccessGenetic variants in the FOXO1 and ZNF469 genes are associated with keratoconus in Sweden: a case-control study
Keratoconus (KC) is characterized by pathological thinning and bulging of the cornea that may lead to visual impairment. The etiology of sporadic KC remains enigmatic despite intensive research in recent decad...
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Article
Open AccessSix-year mortality associated with living alone and loneliness in Swedish men and women born in 1930
This study examined how living alone and loneliness associate with all-cause mortality in older men and women.
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Article
Open AccessThe effect of alcohol consumption on all-cause mortality in 70-year-olds in the context of other lifestyle risk factors: results from the Gothenburg H70 birth cohort study
In this study, we examined the effect of alcohol, as well as the combined effect of seven lifestyle factors, on all-cause mortality in older adults (baseline age 70 years).
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Article
Open AccessMass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies
Blood phosphorylated tau (p-tau) biomarkers, at differing sites, demonstrate high accuracy to detect Alzheimerʼs disease (AD). However, knowledge on the optimal marker for disease identification across the AD ...
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Article
Open AccessCerebrospinal fluid biomarkers of axonal and synaptic degeneration in a population-based sample
Neurofilament light (NfL) and neurogranin (Ng) are promising candidate AD biomarkers, reflecting axonal and synaptic damage, respectively. Since there is a need to understand the synaptic and axonal damage in ...
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Article
Open AccessAuthor Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
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Article
Open AccessHigh polygenic risk score for exceptional longevity is associated with a healthy metabolic profile
Healthy metabolic measures in humans are associated with longevity. Dysregulation leads to metabolic syndrome (MetS) and negative health outcomes. Recent exceptional longevity (EL) genome wide association stud...
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Article
Open AccessGenome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers
Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer’s disease (AD) more directly than clinical diagnosis. Initiated b...
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Author Correction: A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease
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Article
Open AccessInteractions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds
To investigate potential interactions between dietary patterns and genetic factors modulating risk for Alzheimer’s disease (AD) in relation to incident dementia.
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Chapter
Introduction
In 2020, for the first time in history, there were more people in the world aged 60 years and over than there were children below the age of 5 years. The population aged over 65 years is projected to increase fro...
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Chapter
The Capability Approach in Epidemiological Studies
Population epidemiology is the science that deals with disorders and certain conditions at the population level, i.e. at the macro-level. In contrast to experimental studies, the scientist in epidemiology cann...
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Book
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Article
Author Correction: A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease
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Article
Open AccessComparison of the 2010 and 2019 diagnostic criteria for sarcopenia by the European Working Group on Sarcopenia in Older People (EWGSOP) in two cohorts of Swedish older adults
The operational definition of sarcopenia has been updated (EWGSOP2) and apply different cut-off points compared to previous criteria (EWGSOP1). Therefore, we aim to compare the sarcopenia prevalence and the as...
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Article
Open AccessDizziness and health-related quality of life among older adults in an urban population: a cross-sectional study
Dizziness is a common complaint among older adults and may affect quality of life in a negative way. The aim of this study was to assess health-related quality of life (HRQL), sense of coherence (SOC), self-ra...
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Article
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease
Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer’s disease have be...
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Article
Open AccessCommon variants in Alzheimer’s disease and risk stratification by polygenic risk scores
Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curat...
