27 Result(s)
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Siddappa N Byrareddy
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Open AccessIdentification and Biological Characterization of Unique B/C Recombinant Strains of HIV-1 In Southern States of India
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Open AccessPassive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose
A key goal for HIV-1 envelope immunogen design is the induction of cross-reactive neutralizing antibodies (nAbs). As AIDS vaccine recipients will not be exposed to strains exactly matching any immunogens due t...
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Open AccessPlacental Hofbauer cells assemble and sequester HIV-1 in tetraspanin and DC SIGN positive compartments that are accessible to neutralizing antibodies
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Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection
Aftab Ansari and his colleagues show that antibody-mediated masking of α4β7 integrin impedes intravaginal transmission of simian immunodeficiency virus in macaques.
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Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy–treated macaques
ImmunoPET/CT imaging using a labeled SIV-specific antibody can identify sites of viralinfection in SIV-infected macaques without the need for tissue biopsies, even if viral load in the blood is below the detec...
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Erratum: Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy–treated macaques
Nat. Methods 12, 427–432 (2015); published online 9 March 2015; corrected after print 11 June 2015 In the version of this article initially published, the first name of Emmeline L. Blanchard was misspelled as ...
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Host-Virus Interaction of ZIKA Virus in Modulating Disease Pathogenesis
The Zika virus (ZIKV) is a newly emerging pathogen that has resulted in a worldwide epidemic. It primarily spreads either through infected Aedes aegypti or Aedes albopictus mosquitos leading to severe neurologica...
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Open AccessNormalization of cell associated antiretroviral drug concentrations with a novel RPP30 droplet digital PCR assay
Quantification of antiretroviral (ARV) drug concentrations in peripheral blood mononuclear cells (PBMCs) and tissue isolated mononuclear cells (TIMCs) from lymph node (LNMC) and rectum (RMC) is an important me...
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Open AccessThe Role of Integrin α4β7 in HIV Pathogenesis and Treatment
Acute HIV infection is characterized by high-level viral replication throughout the body’s lymphoid system, particularly in gut-associated lymphoid tissues resulting in damage to structural components of gut t...
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Functional Meningeal Lymphatics and Cerebrospinal Fluid Outflow
Functional meningeal lymphatic system plays a crucial role in outflow of cerebrospinal fluid. Metabolites and neurotoxins in the cerebrospinal fluid may be excreted via this system and accumulate in the cervic...
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FDC:TFH Interactions within Cervical Lymph Nodes of SIV-Infected Rhesus Macaques
Cerebrospinal fluid (CSF) drains via the lymphatic drainage pathway. This lymphatic pathway connects the central nervous system (CNS) to the cervical lymph node (CLN). As the CSF drains to CLN via the dural an...
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In vivo characterization of macrophage-tropic simian immunodeficiency virus molecular clones in rhesus macaques
Macrophages are a major target of HIV/SIV infection and play an important role in pathogenesis by serving as viral reservoirs in the central nervous system. Previously, a unique early SIVmac251 envelope (Env) ...
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Correction to: Zika Virus and the Metabolism of Neuronal Cells
The original version of this article unfortunately contained mistake.
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Zika Virus and the Metabolism of Neuronal Cells
Zika virus (ZIKV) infection is associated with abnormal functions of neuronal cells causing neurological disorders such as microcephaly in the newborns and Guillain–Barré syndrome in the adults. Typically, hea...
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Open AccessA Tat/Rev Induced Limiting Dilution Assay to Measure Viral Reservoirs in Non-Human Primate Models of HIV Infection
The establishment of latent infection and poorly characterized viral reservoirs in tissues represent major obstacles to a definitive cure for HIV. Non-human primate (NHP) models of HIV infection are critical t...
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Recent Advances in the Development of Integrase Inhibitors for HIV Treatment
The complex multistep life cycle of HIV allows it to proliferate within the host and integrate its genome in to the host chromosomal DNA. This provirus can remain dormant for an indefinite period. The process ...
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SARS-CoV-2 Infection Leads to Neurological Dysfunction
A number of neurological disease complications have been seen following infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While most person with COVID-19 respiratory disease demo...
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Immuno-epidemiology and pathophysiology of coronavirus disease 2019 (COVID-19)
Occasional zoonotic viral attacks on immunologically naive populations result in massive death tolls that are capable of threatening human survival. Currently, severe acute respiratory syndrome coronavirus 2 (...
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Infectivity of SARS-CoV-2: there Is Something More than D614G?
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Open AccessZika virus infection induces endoplasmic reticulum stress and apoptosis in placental trophoblasts
Zika virus (ZIKV) infection to a pregnant woman can be vertically transmitted to the fetus via the placenta leading to Congenital Zika syndrome. This is characterized by microcephaly, retinal defects, and intr...
